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Clcnkb chloride channel, voltage-sensitive Kb [ Mus musculus (house mouse) ]

Gene ID: 56365, updated on 8-Dec-2022

Summary

Official Symbol
Clcnkbprovided by MGI
Official Full Name
chloride channel, voltage-sensitive Kbprovided by MGI
Primary source
MGI:MGI:1930643
See related
Ensembl:ENSMUSG00000006216 AllianceGenome:MGI:1930643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLCKB; Clck2; Clc-Ka; Clcnk2; Clcnk1l
Summary
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKA (geneID:1187). [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward kidney adult (RPKM 97.2) See more
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Genomic context

See Clcnkb in Genome Data Viewer
Location:
4; 4 D3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141131668..141143440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141404357..141416055, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive Ka Neighboring gene predicted gene, 34693 Neighboring gene heat shock protein family, member 7 (cardiovascular) Neighboring gene steroid receptor associated and regulated protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chloride channel protein ClC-Kb
Names
chloride channel K1-like; putative basolateral cTAL chloride channel ClC-Ka
chloride channel Kb
clC-K2
putative basolateral mTAL chloride channel ClC-Ka

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019701.2NP_062675.2  chloride channel protein ClC-Kb

    See identical proteins and their annotated locations for NP_062675.2

    Status: VALIDATED

    Source sequence(s)
    AA240610, AK146876, BB845352, BX636867
    Consensus CDS
    CCDS18872.1
    UniProtKB/Swiss-Prot
    Q8VCF8, Q9WUB6
    Related
    ENSMUSP00000006378.3, ENSMUST00000006378.9
    Conserved Domains (2) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:546676
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141131668..141143440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539067.4XP_006539130.1  chloride channel protein ClC-Kb isoform X3

    Conserved Domains (2) summary
    cd03683
    Location:49475
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:488618
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  2. XM_006539066.4XP_006539129.1  chloride channel protein ClC-Kb isoform X2

    See identical proteins and their annotated locations for XP_006539129.1

    Conserved Domains (2) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:546648
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  3. XM_011250307.3XP_011248609.1  chloride channel protein ClC-Kb isoform X1

    See identical proteins and their annotated locations for XP_011248609.1

    UniProtKB/Swiss-Prot
    Q8VCF8, Q9WUB6
    Conserved Domains (2) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:546676
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  4. XM_006539068.4XP_006539131.1  chloride channel protein ClC-Kb isoform X4

    Conserved Domains (1) summary
    cl02915
    Location:49341
    Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...