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Mettl3 methyltransferase like 3 [ Mus musculus (house mouse) ]

Gene ID: 56335, updated on 29-Jan-2023

Summary

Official Symbol
Mettl3provided by MGI
Official Full Name
methyltransferase like 3provided by MGI
Primary source
MGI:MGI:1927165
See related
Ensembl:ENSMUSG00000022160 AllianceGenome:MGI:1927165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M6A; Spo8; 2310024F18Rik
Summary
Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and gamete generation. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in genitourinary system. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl3 in Genome Data Viewer
Location:
14; 14 C2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52532298..52548555, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52294841..52308741, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene predicted gene, 26590 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene predicted gene, 23758 Neighboring gene TOX high mobility group box family member 4 Neighboring gene spalt like transcription factor 2 Neighboring gene predicted gene, 53857 Neighboring gene predicted gene, 26328

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA (N6-adenosine)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA (N6-adenosine)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA (N6-adenosine)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mRNA (N6-adenosine)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within RNA methylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dosage compensation by inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
 
involved_in forebrain radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA methylation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mRNA modification ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cap-independent translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
N6-adenosine-methyltransferase subunit METTL3
Names
MT-A70
N6-adenosine-methyltransferase 70 kDa subunit
m6a methyltransferase
methyltransferase-like protein 3
NP_062695.2
XP_006519374.1
XP_017171585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019721.2NP_062695.2  N6-adenosine-methyltransferase subunit METTL3

    See identical proteins and their annotated locations for NP_062695.2

    Status: VALIDATED

    Source sequence(s)
    AK085189, BE979768, BY108113
    Consensus CDS
    CCDS27053.1
    UniProtKB/Swiss-Prot
    Q8C3P7
    UniProtKB/TrEMBL
    A0A0R4J041, A0A8C6HR14
    Related
    ENSMUSP00000022767.10, ENSMUST00000022767.16
    Conserved Domains (2) summary
    pfam05063
    Location:389550
    MT-A70; MT-A70
    pfam08619
    Location:1779
    Nha1_C; Alkali metal cation/H+ antiporter Nha1 C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52532298..52548555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519311.5XP_006519374.1  N6-adenosine-methyltransferase subunit METTL3 isoform X1

    Conserved Domains (1) summary
    pfam05063
    Location:234395
    MT-A70
  2. XM_017316096.3XP_017171585.1  N6-adenosine-methyltransferase subunit METTL3 isoform X1

    Conserved Domains (1) summary
    pfam05063
    Location:234395
    MT-A70

RNA

  1. XR_001781134.3 RNA Sequence