METTL3 methyltransferase like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: METTL3provided by HGNC
Official Full Name: methyltransferase like 3provided by HGNC
Primary source: HGNC:HGNC:17563
See related: Ensembl:ENSG00000165819 MIM:612472
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: M6A; IME4; Spo8; MT-A70; hMETTL3
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	14	NC_000014.9 (21498138..21511340, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (21966282..21979482, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8.
Title: Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8.
METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance.
Title: METTL3-mediated m<sup>6</sup>A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance.
METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
Title: METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution.
Title: TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution.
m6A RNA methylation regulators correlate with malignant progression and have potential predictive values in clear cell renal cell carcinoma.
Title: m6A RNA methylation regulators correlate with malignant progression and have potential predictive values in clear cell renal cell carcinoma.
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Title: Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Title: Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Title: METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway.
Title: N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway.
In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis.
Title: In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44762 (e-PCR)
- UniSTS:32768

SHGC-64027 (e-PCR)
- UniSTS:31045

SHGC-36315 (e-PCR)
- UniSTS:873

D15S1477 (e-PCR)
- UniSTS:474482

Homology

Homologs of the METTL3 gene: The METTL3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 285 organisms have orthologs with human gene METTL3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
S-adenosyl-L-methionine binding	IDA Inferred from Direct Assay more info	PubMed
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
mRNA (N6-adenosine)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
mRNA (N6-adenosine)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
mRNA binding	IDA Inferred from Direct Assay more info	PubMed
methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
RNA metabolic process	TAS Traceable Author Statement more info
RNA methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
adenosine to inosine editing	ISS Inferred from Sequence or Structural Similarity more info
cellular response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
dosage compensation by inactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed
endothelial to hematopoietic transition	ISS Inferred from Sequence or Structural Similarity more info
forebrain radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
gliogenesis	ISS Inferred from Sequence or Structural Similarity more info
innate immune response	IEA Inferred from Electronic Annotation more info
mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
mRNA methylation	IDA Inferred from Direct Assay more info	PubMed
mRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
NOT mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cap-independent translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
primary miRNA methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
primary miRNA methylation	IDA Inferred from Direct Assay more info	PubMed
primary miRNA processing	IDA Inferred from Direct Assay more info	PubMed
regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of hematopoietic stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
nuclear speck	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear speck	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N6-adenosine-methyltransferase catalytic subunit

Names: N6-adenosine-methyltransferase 70 kDa subunit; adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; methyltransferase-like protein 3

NP_062826.2

EC 2.1.1.348

XP_006720269.1

EC 2.1.1.348

XP_011535270.1

EC 2.1.1.348

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019852.5 → NP_062826.2 N6-adenosine-methyltransferase catalytic subunit

See identical proteins and their annotated locations for NP_062826.2

Status: REVIEWED

Source sequence(s)

AL161747, BC001650, CA311761, DC295053

Consensus CDS

CCDS32044.1

UniProtKB/Swiss-Prot

Q86U44

Related

ENSP00000298717.3, ENST00000298717.9

Conserved Domains (1) summary

pfam05063
Location:389 → 550

MT-A70

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p13 Primary Assembly

Range

21498138..21511340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006720206.4 → XP_006720269.1 N6-adenosine-methyltransferase catalytic subunit isoform X2

Conserved Domains (1) summary

pfam05063
Location:105 → 266

MT-A70
XM_011536968.2 → XP_011535270.1 N6-adenosine-methyltransferase catalytic subunit isoform X1

Conserved Domains (1) summary

cl01947
Location:389 → 528

MT-A70; MT-A70