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METTL3 methyltransferase like 3 [ Homo sapiens (human) ]

Gene ID: 56339, updated on 22-Mar-2020

Summary

Official Symbol
METTL3provided by HGNC
Official Full Name
methyltransferase like 3provided by HGNC
Primary source
HGNC:HGNC:17563
See related
Ensembl:ENSG00000165819 MIM:612472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M6A; IME4; Spo8; MT-A70; hMETTL3
Summary
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues See more
Orthologs

Genomic context

See METTL3 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21498138..21511340, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21966282..21979517, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene RNA, 7SL, cytoplasmic 650, pseudogene Neighboring gene RAB2B, member RAS oncogene family Neighboring gene TOX high mobility group box family member 4 Neighboring gene spalt like transcription factor 2 Neighboring gene RBBP4 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4336

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
mRNA (N6-adenosine)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA (N6-adenosine)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenosine to inosine editing ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
endothelial to hematopoietic transition ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gliogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cap-independent translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
primary miRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
primary miRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N6-adenosine-methyltransferase catalytic subunit
Names
N6-adenosine-methyltransferase 70 kDa subunit
adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
mRNA m(6)A methyltransferase
methyltransferase-like protein 3
NP_062826.2
XP_006720269.1
XP_011535270.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019852.5NP_062826.2  N6-adenosine-methyltransferase catalytic subunit

    See identical proteins and their annotated locations for NP_062826.2

    Status: REVIEWED

    Source sequence(s)
    AL161747, BC001650, CA311761, DC295053
    Consensus CDS
    CCDS32044.1
    UniProtKB/Swiss-Prot
    Q86U44
    Related
    ENSP00000298717.3, ENST00000298717.9
    Conserved Domains (1) summary
    pfam05063
    Location:389550
    MT-A70; MT-A70

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21498138..21511340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720206.4XP_006720269.1  N6-adenosine-methyltransferase catalytic subunit isoform X2

    Conserved Domains (1) summary
    pfam05063
    Location:105266
    MT-A70; MT-A70
  2. XM_011536968.2XP_011535270.1  N6-adenosine-methyltransferase catalytic subunit isoform X1

    Conserved Domains (1) summary
    cl01947
    Location:389528
    MT-A70; MT-A70

RNA

  1. XR_001750438.2 RNA Sequence

    Related
    ENST00000543235.5
  2. XR_001750439.2 RNA Sequence

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