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SLC7A10 solute carrier family 7 member 10 [ Homo sapiens (human) ]

Gene ID: 56301, updated on 24-May-2020

Summary

Official Symbol
SLC7A10provided by HGNC
Official Full Name
solute carrier family 7 member 10provided by HGNC
Primary source
HGNC:HGNC:11058
See related
Ensembl:ENSG00000130876 MIM:607959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASC1; asc-1; HASC-1
Summary
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in fat (RPKM 24.7), ovary (RPKM 10.1) and 14 other tissues See more
Orthologs

Genomic context

See SLC7A10 in Genome Data Viewer
Location:
19q13.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (33208664..33225850, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33699570..33716756, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 88 Neighboring gene tRNA-Thr (anticodon AGT) 1-3 Neighboring gene LDL receptor related protein 3 Neighboring gene HNF1 motif-containing MPRA enhancer 13 Neighboring gene CCAAT enhancer binding protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20839

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-serine transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
neutral amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutral amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
D-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D-serine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
L-serine transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutral amino acid transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
asc-type amino acid transporter 1
Names
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
solute carrier family 7, (cationic amino acid transporter, y+ system) member 10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019849.3NP_062823.1  asc-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_062823.1

    Status: VALIDATED

    Source sequence(s)
    AB037670, BC022457
    Consensus CDS
    CCDS12431.1
    UniProtKB/Swiss-Prot
    Q9NS82
    Related
    ENSP00000253188.2, ENST00000253188.8
    Conserved Domains (1) summary
    cl26159
    Location:15498
    AA_permease_2; Amino acid permease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    33208664..33225850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451610.1XP_024307378.1  asc-type amino acid transporter 1 isoform X4

    Conserved Domains (2) summary
    cl26159
    Location:97471
    AA_permease_2; Amino acid permease
    cl26386
    Location:284
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_011527120.1XP_011525422.1  asc-type amino acid transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:97608
    2A0308; L-type amino acid transporter
  3. XM_006723284.2XP_006723347.1  asc-type amino acid transporter 1 isoform X5

    Conserved Domains (1) summary
    TIGR00911
    Location:15419
    2A0308; L-type amino acid transporter
  4. XM_024451609.1XP_024307377.1  asc-type amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    cl26159
    Location:15304
    AA_permease_2; Amino acid permease
  5. XM_011527119.1XP_011525421.1  asc-type amino acid transporter 1 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:15635
    2A0308; L-type amino acid transporter

RNA

  1. XR_935841.1 RNA Sequence

    Related
    ENST00000590036.5
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