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Slc7a10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 [ Mus musculus (house mouse) ]

Gene ID: 53896, updated on 2-Nov-2024

Summary

Official Symbol
Slc7a10provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10provided by MGI
Primary source
MGI:MGI:1858261
See related
Ensembl:ENSMUSG00000030495 AllianceGenome:MGI:1858261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asc-1; D7Bwg0847e
Summary
Enables neutral L-amino acid transmembrane transporter activity. Involved in negative regulation of brown fat cell differentiation; neutral amino acid transport; and positive regulation of glycinergic synaptic transmission. Acts upstream of or within D-alanine transmembrane transport. Located in plasma membrane. Is expressed in brain; embryo mesenchyme; naris; and spinal cord ventricular layer. Orthologous to human SLC7A10 (solute carrier family 7 member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 132.8), mammary gland adult (RPKM 77.6) and 7 other tissues See more
Orthologs
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Genomic context

See Slc7a10 in Genome Data Viewer
Location:
7 B2; 7 21.13 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34885520..34900539)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35186095..35201116)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35889 Neighboring gene predicted gene, 38988 Neighboring gene low density lipoprotein receptor-related protein 3 Neighboring gene predicted gene, 24505 Neighboring gene predicted gene, 38989 Neighboring gene nuclear encoded tRNA threonine 9 (anticodon AGT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
asc-type amino acid transporter 1
Names
D-serine transporter
solute carrier family 7 member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017394.4NP_059090.3  asc-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_059090.3

    Status: VALIDATED

    Source sequence(s)
    AC150683, BC054765
    Consensus CDS
    CCDS21146.1
    UniProtKB/Swiss-Prot
    P63115, Q9CW25, Q9JMH8
    UniProtKB/TrEMBL
    Q8C0A7
    Related
    ENSMUSP00000001854.6, ENSMUST00000001854.12
    Conserved Domains (1) summary
    TIGR00911
    Location:38503
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    34885520..34900539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242780.1XP_030098640.1  asc-type amino acid transporter 1 isoform X1

    UniProtKB/TrEMBL
    Q8C0A7
    Conserved Domains (1) summary
    TIGR00911
    Location:38453
    2A0308; L-type amino acid transporter
  2. XM_006540197.5XP_006540260.1  asc-type amino acid transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:38376
    2A0308; L-type amino acid transporter
  3. XM_030242782.1XP_030098642.1  asc-type amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:26354
    2A0308; L-type amino acid transporter

RNA

  1. XR_004934149.1 RNA Sequence