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AZGP1 alpha-2-glycoprotein 1, zinc-binding [ Homo sapiens (human) ]

Gene ID: 563, updated on 9-Dec-2018

Summary

Official Symbol
AZGP1provided by HGNC
Official Full Name
alpha-2-glycoprotein 1, zinc-bindingprovided by HGNC
Primary source
HGNC:HGNC:910
See related
Ensembl:ENSG00000160862 MIM:194460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAG; ZA2G
Expression
Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues See more
Orthologs

Genomic context

See AZGP1 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (99966727..99976112, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99564350..99573735, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 4 Neighboring gene uncharacterized LOC101927610 Neighboring gene gap junction protein gamma 3 Neighboring gene AZGP1 pseudogene 1 Neighboring gene gap junction protein gamma 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
ribonuclease activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
retina homeostasis HEP PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc-alpha-2-glycoprotein
Names
Alpha-2-glycoprotein, zinc
Zn-alpha2-glycoprotein
testicular tissue protein Li 227
zn-alpha-2-GP
zn-alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185.4NP_001176.1  zinc-alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_001176.1

    Status: VALIDATED

    Source sequence(s)
    BC005306, BC033830
    Consensus CDS
    CCDS5680.1
    UniProtKB/Swiss-Prot
    P25311
    UniProtKB/TrEMBL
    A0A140VK00
    Related
    ENSP00000292401.4, ENST00000292401.8
    Conserved Domains (2) summary
    cd07698
    Location:205296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:26201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    99966727..99976112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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