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AZGP1 alpha-2-glycoprotein 1, zinc-binding [ Homo sapiens (human) ]

Gene ID: 563, updated on 3-Nov-2024

Summary

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Official Symbol
AZGP1provided by HGNC
Official Full Name
alpha-2-glycoprotein 1, zinc-bindingprovided by HGNC
Primary source
HGNC:HGNC:910
See related
Ensembl:ENSG00000160862 MIM:194460; AllianceGenome:HGNC:910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAG; ZA2G
Summary
Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. Implicated in prostate carcinoma. Biomarker of several diseases, including gastrointestinal system cancer (multiple); kidney failure (multiple); liver cirrhosis; lung adenocarcinoma; and obesity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues See more
Orthologs
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Genomic context

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See AZGP1 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99966730..99976031, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101206237..101220128, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99564353..99573654, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99526456-99527041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99527042-99527626 Neighboring gene gap junction protein gamma 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99541581-99542436 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99543294-99544149 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99580686-99580841 Neighboring gene AZGP1 pseudogene 1 Neighboring gene gap junction protein gamma 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc alpha2 glycoprotein alleviates palmitic acid-induced intracellular lipid accumulation in hepatocytes. Xiao X, et al. Mol Cell Endocrinol, 2017 Jan 5. PMID 27264075
  2. Con A-binding protein Zn-α2-glycoprotein on human sperm membrane is related to acrosome reaction and sperm fertility. Liu Y, et al. Int J Androl, 2012 Apr. PMID 21790656
  3. Serum levels of the adipokine zinc-α2-glycoprotein are increased in preeclampsia. Stepan H, et al. J Endocrinol Invest, 2012 Jun. PMID 21791968
  4. rs4215 SNP in zinc-α2-glycoprotein gene is associated with obesity in Chinese north Han population. Zhu HJ, et al. Gene, 2012 Jun 1. PMID 22425975
  5. Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. Garrido-Sánchez L, et al. PLoS One, 2012. PMID 22442679, Free PMC Article

See all (208) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
    Title: Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
  2. AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
    Title: AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
  3. RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD.
    Title: RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD.
  4. AZGP1 deficiency promotes angiogenesis in prostate cancer.
    Title: AZGP1 deficiency promotes angiogenesis in prostate cancer.
  5. Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
    Title: Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
  6. Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
    Title: Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
  7. Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
    Title: Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
  8. CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
    Title: CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
  9. Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc alpha2-Glycoprotein and Associated Genes in Obesity.
    Title: Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc α2-Glycoprotein and Associated Genes in Obesity.
  10. Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
    Title: Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA nuclease activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
zinc-alpha-2-glycoprotein
Names
Alpha-2-glycoprotein, zinc
Zn-alpha2-glycoprotein
testicular tissue protein Li 227
zn-alpha-2-GP
zn-alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185.4 → NP_001176.1  zinc-alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_001176.1

    Status: VALIDATED

    Source sequence(s)
    BC005306, BC033830
    Consensus CDS
    CCDS5680.1
    UniProtKB/Swiss-Prot
    D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
    UniProtKB/TrEMBL
    A0A140VK00
    Related
    ENSP00000292401.4, ENST00000292401.9
    Conserved Domains (2) summary
    cd07698
    Location:205 → 296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:26 → 201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99966730..99976031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101206237..101220128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358658.1 → XP_054214633.1  zinc-alpha-2-glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
    UniProtKB/TrEMBL
    A0A140VK00

  2. XM_054358657.1 → XP_054214632.1  zinc-alpha-2-glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
    UniProtKB/TrEMBL
    A0A140VK00
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25311.2 GenPept UniProtKB/Swiss-Prot:P25311

Gene LinkOut

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