U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Azgp1 alpha-2-glycoprotein 1, zinc [ Mus musculus (house mouse) ]

Gene ID: 12007, updated on 8-Feb-2024

Summary

Official Symbol
Azgp1provided by MGI
Official Full Name
alpha-2-glycoprotein 1, zincprovided by MGI
Primary source
MGI:MGI:103163
See related
Ensembl:ENSMUSG00000037053 AllianceGenome:MGI:103163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zag
Summary
Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; detection of chemical stimulus involved in sensory perception of bitter taste; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and liver and biliary system. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 435.9) and liver E18 (RPKM 299.4) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Azgp1 in Genome Data Viewer
Location:
5 G2; 5 76.92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137979783..137988495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137981521..137990233)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14660 Neighboring gene ZW10 interactor pseudogene Neighboring gene STARR-seq mESC enhancer starr_14661 Neighboring gene gap junction protein, gamma 3 Neighboring gene predicted gene 4963 Neighboring gene STARR-seq mESC enhancer starr_14662 Neighboring gene STARR-seq mESC enhancer starr_14663 Neighboring gene sperm motility kinase 3A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of multicellular organism growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc-alpha-2-glycoprotein
Names
major histocompatibility complex class I-like protein
zn-alpha-2-GP

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013478.2NP_038506.2  zinc-alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_038506.2

    Status: VALIDATED

    Source sequence(s)
    AK005051, BY101787, BY705112, D18019
    Consensus CDS
    CCDS19783.1
    UniProtKB/Swiss-Prot
    Q64726, Q9DBB7
    Related
    ENSMUSP00000038559.6, ENSMUST00000035390.7
    Conserved Domains (2) summary
    cl08246
    Location:21196
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:200291
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137979783..137988495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)