Format

Send to:

Choose Destination

PROX1 prospero homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5629, updated on 18-May-2019

Summary

Official Symbol
PROX1provided by HGNC
Official Full Name
prospero homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9459
See related
Ensembl:ENSG00000117707 MIM:601546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Biased expression in liver (RPKM 20.2), adrenal (RPKM 5.1) and 13 other tissues See more
Orthologs

Genomic context

See PROX1 in Genome Data Viewer
Location:
1q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (213983239..214041510)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214161278..214214853)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372912 Neighboring gene ribosomal protein L31 pseudogene 13 Neighboring gene PROX1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 538 Neighboring gene long intergenic non-protein coding RNA 2775 Neighboring gene VISTA enhancer hs2357 Neighboring gene uncharacterized LOC107985263 Neighboring gene SET and MYND domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of prospero homeobox 1 (PROX1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21800

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acinar cell differentiation IEA
Inferred from Electronic Annotation
more info
 
aorta smooth muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
atrial cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
branching involved in pancreas morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell fate determination IEA
Inferred from Electronic Annotation
more info
 
cerebellar granule cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
dentate gyrus development ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal spinal cord development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
embryonic retina morphogenesis in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
endocardium formation ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatocyte cell migration IEA
Inferred from Electronic Annotation
more info
 
hepatocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
lens development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
lens fiber cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lens fiber cell morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
lung development IEP
Inferred from Expression Pattern
more info
PubMed 
lymphangiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphangiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
lymphatic endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphatic endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bile acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuronal stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory placode formation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
optic placode formation involved in camera-type eye formation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
otic placode formation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
pancreas development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle checkpoint IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of forebrain neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heart growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sarcomere organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription involved in lymphatic endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
retina morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
skeletal muscle thin filament assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
venous blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prospero homeobox protein 1
Names
homeobox prospero-like protein PROX1
prospero-related homeobox 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270616.2NP_001257545.1  prospero homeobox protein 1

    See identical proteins and their annotated locations for NP_001257545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011700, AL606537
    Consensus CDS
    CCDS31021.1
    UniProtKB/Swiss-Prot
    Q92786
    Related
    ENSP00000355925.4, ENST00000366958.8
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain
  2. NM_002763.4NP_002754.2  prospero homeobox protein 1

    See identical proteins and their annotated locations for NP_002754.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL606537, BC024201, DA743374
    Consensus CDS
    CCDS31021.1
    UniProtKB/Swiss-Prot
    Q92786
    Related
    ENSP00000400694.1, ENST00000435016.2
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    213983239..214041510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509773.2XP_011508075.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508075.1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
  2. XM_011509771.1XP_011508073.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508073.1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
  3. XM_005273194.2XP_005273251.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005273251.1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
  4. XM_005273195.4XP_005273252.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005273252.1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
  5. XM_017001833.1XP_016857322.1  prospero homeobox protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q92786
    Conserved Domains (1) summary
    pfam05044
    Location:579730
    HPD; Homeo-prospero domain
  6. XM_011509772.2XP_011508074.1  prospero homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508074.1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
  7. XM_017001832.1XP_016857321.1  prospero homeobox protein 1 isoform X1

    Conserved Domains (2) summary
    pfam05044
    Location:579731
    HPD; Homeo-prospero domain
    pfam09805
    Location:229278
    Nop25; Nucleolar protein 12 (25kDa)
Support Center