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Gkap1 G kinase anchoring protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56278, updated on 26-Sep-2022

Summary

Official Symbol
Gkap1provided by MGI
Official Full Name
G kinase anchoring protein 1provided by MGI
Primary source
MGI:MGI:1891694
See related
Ensembl:ENSMUSG00000021552 AllianceGenome:MGI:1891694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
42kDa; Gkap42; D13Ertd340e; 4933400B15Rik
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of insulin receptor signaling pathway and signal transduction. Located in Golgi apparatus. Is expressed in several structures, including aorta; genitourinary system; gut gland; nervous system; and trachea. Orthologous to human GKAP1 (G kinase anchoring protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 36.7), placenta adult (RPKM 11.9) and 15 other tissues See more
Orthologs
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Genomic context

See Gkap1 in Genome Data Viewer
Location:
13 B1; 13 30.97 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58381160..58422691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58233346..58274877, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene predicted gene, 26555 Neighboring gene kinesin family member 27 Neighboring gene microRNA 6369 Neighboring gene RIKEN cDNA 2210016F16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G kinase-anchoring protein 1
Names
42 kD cGMP-dependent protein kinase anchoring protein
cGMP-dependent protein kinase anchoring protein
cGMP-dependent protein kinase-anchoring protein of 42 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019832.4NP_062806.1  G kinase-anchoring protein 1

    See identical proteins and their annotated locations for NP_062806.1

    Status: VALIDATED

    Source sequence(s)
    BC052347, W84281
    Consensus CDS
    CCDS36684.1
    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Related
    ENSMUSP00000089169.5, ENSMUST00000091579.6
    Conserved Domains (1) summary
    COG1196
    Location:188349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58381160..58422691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244542.3XP_011242844.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242844.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. XM_030247329.2XP_030103189.1  G kinase-anchoring protein 1 isoform X2

  3. XM_006517304.5XP_006517367.1  G kinase-anchoring protein 1 isoform X2

  4. XM_030247330.2XP_030103190.1  G kinase-anchoring protein 1 isoform X2

  5. XM_011244543.4XP_011242845.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242845.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  6. XM_036158099.1XP_036013992.1  G kinase-anchoring protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CUD8
    Conserved Domains (1) summary
    COG1196
    Location:188349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  7. XM_006517301.3XP_006517364.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006517364.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]