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GKAP1 G kinase anchoring protein 1 [ Homo sapiens (human) ]

Gene ID: 80318, updated on 7-Jun-2020

Summary

Official Symbol
GKAP1provided by HGNC
Official Full Name
G kinase anchoring protein 1provided by HGNC
Primary source
HGNC:HGNC:17496
See related
Ensembl:ENSG00000165113 MIM:611356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKSG21; GKAP42
Summary
This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Biased expression in testis (RPKM 88.6) and ovary (RPKM 4.2) See more
Orthologs

Genomic context

See GKAP1 in Genome Data Viewer
Location:
9q21.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (83739421..83817837, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (86354336..86444431, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene IDNK gluconokinase Neighboring gene ubiquilin 1 Neighboring gene uncharacterized LOC105376114 Neighboring gene uncharacterized LOC101927552 Neighboring gene kinesin family member 27 Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene chromosome 9 open reading frame 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
G kinase-anchoring protein 1
Names
cGMP-dependent protein kinase anchoring protein 42kDa
cGMP-dependent protein kinase-anchoring protein of 42 kDa
protein kinase anchoring protein GKAP42

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135953.1NP_001129425.1  G kinase-anchoring protein 1 isoform b

    See identical proteins and their annotated locations for NP_001129425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AB033132, BC014476, BI459540, DB454445
    Consensus CDS
    CCDS47988.1
    UniProtKB/Swiss-Prot
    Q5VSY0
    Related
    ENSP00000365544.3, ENST00000376365.7
    Conserved Domains (1) summary
    cl25732
    Location:103298
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_025211.4NP_079487.2  G kinase-anchoring protein 1 isoform a

    See identical proteins and their annotated locations for NP_079487.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC014476, BI459540, DB454445
    Consensus CDS
    CCDS35049.1
    UniProtKB/Swiss-Prot
    Q5VSY0
    Related
    ENSP00000365550.2, ENST00000376371.7
    Conserved Domains (1) summary
    cl25732
    Location:163349
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    83739421..83817837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519058.2XP_011517360.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011517360.1

    UniProtKB/Swiss-Prot
    Q5VSY0
    Conserved Domains (1) summary
    cl25732
    Location:163349
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_005252241.2XP_005252298.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005252298.1

    UniProtKB/Swiss-Prot
    Q5VSY0
    Conserved Domains (1) summary
    cl25732
    Location:163349
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_006717293.1XP_006717356.1  G kinase-anchoring protein 1 isoform X2

    Conserved Domains (1) summary
    TIGR02168
    Location:39225
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_017015171.1XP_016870660.1  G kinase-anchoring protein 1 isoform X2

    Conserved Domains (1) summary
    TIGR02168
    Location:39225
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
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