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IRGC immunity related GTPase cinema [ Homo sapiens (human) ]

Gene ID: 56269, updated on 23-Nov-2021

Summary

Official Symbol
IRGCprovided by HGNC
Official Full Name
immunity related GTPase cinemaprovided by HGNC
Primary source
HGNC:HGNC:28835
See related
Ensembl:ENSG00000124449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFGGE; IRGC1; Iigp5; CINEMA; R30953_1
Expression
Restricted expression toward testis (RPKM 28.8) See more
Orthologs
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Genomic context

See IRGC in Genome Data Viewer
Location:
19q13.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43716068..43720021)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44220228..44224173)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene plasminogen activator, urokinase receptor Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene potassium calcium-activated channel subfamily N member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon-inducible GTPase 5
Names
immunity-related GTPase cinema 1
immunity-related GTPase family, cinema 1
interferon-gamma-inducible GTPase IFGGE protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019612.4NP_062558.1  interferon-inducible GTPase 5

    See identical proteins and their annotated locations for NP_062558.1

    Status: VALIDATED

    Source sequence(s)
    BC033853, BC066939
    Consensus CDS
    CCDS12629.1
    UniProtKB/Swiss-Prot
    Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Related
    ENSP00000244314.5, ENST00000244314.6
    Conserved Domains (2) summary
    cd04104
    Location:54250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:1276
    DUF258; Protein of unknown function, DUF258

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43716068..43720021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723283.3XP_006723346.1  interferon-inducible GTPase 5 isoform X2

    See identical proteins and their annotated locations for XP_006723346.1

    UniProtKB/Swiss-Prot
    Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Conserved Domains (2) summary
    cd04104
    Location:54250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:1276
    DUF258; Protein of unknown function, DUF258
  2. XM_005259058.3XP_005259115.1  interferon-inducible GTPase 5 isoform X1

    See identical proteins and their annotated locations for XP_005259115.1

    Conserved Domains (3) summary
    cd04104
    Location:91287
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:59440
    IIGP; Interferon-inducible GTPase (IIGP)
    cl21455
    Location:55113
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011527118.3XP_011525420.1  interferon-inducible GTPase 5 isoform X2

    See identical proteins and their annotated locations for XP_011525420.1

    UniProtKB/Swiss-Prot
    Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Conserved Domains (2) summary
    cd04104
    Location:54250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:1276
    DUF258; Protein of unknown function, DUF258
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