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Ramp3 receptor (calcitonin) activity modifying protein 3 [ Mus musculus (house mouse) ]

Gene ID: 56089, updated on 21-Apr-2024

Summary

Official Symbol
Ramp3provided by MGI
Official Full Name
receptor (calcitonin) activity modifying protein 3provided by MGI
Primary source
MGI:MGI:1860292
See related
Ensembl:ENSMUSG00000041046 AllianceGenome:MGI:1860292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables coreceptor activity. Involved in G protein-coupled receptor signaling pathway involved in heart process and cellular response to estradiol stimulus. Acts upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in alimentary system; central nervous system; heart; lung; and metanephros. Orthologous to human RAMP3 (receptor activity modifying protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 64.0), subcutaneous fat pad adult (RPKM 53.0) and 9 other tissues See more
Orthologs
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Genomic context

Location:
11 A1; 11 4.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6608507..6627478)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6658506..6677478)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta regulated gene 4 Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene whey acidic protein Neighboring gene predicted gene 11978 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene predicted gene, 39575

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables amylin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of adrenomedullin receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of amylin receptor complex 3 ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor activity-modifying protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019511.3NP_062384.1  receptor activity-modifying protein 3 precursor

    See identical proteins and their annotated locations for NP_062384.1

    Status: VALIDATED

    Source sequence(s)
    AL603787
    Consensus CDS
    CCDS24425.1
    UniProtKB/Swiss-Prot
    Q5SWP4, Q9WUP1
    Related
    ENSMUSP00000047518.8, ENSMUST00000045374.8
    Conserved Domains (1) summary
    pfam04901
    Location:37144
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6608507..6627478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514761.5XP_006514824.1  receptor activity-modifying protein 3 isoform X1

    Related
    ENSMUST00000139540.2
    Conserved Domains (1) summary
    pfam04901
    Location:6113
    RAMP; Receptor activity modifying family