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RAMP3 receptor activity modifying protein 3 [ Homo sapiens (human) ]

Gene ID: 10268, updated on 22-Aug-2021

Summary

Official Symbol
RAMP3provided by HGNC
Official Full Name
receptor activity modifying protein 3provided by HGNC
Primary source
HGNC:HGNC:9845
See related
Ensembl:ENSG00000122679 MIM:605155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 28.4), lymph node (RPKM 13.1) and 20 other tissues See more
Orthologs
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Genomic context

See RAMP3 in Genome Data Viewer
Location:
7p13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (45157778..45184250)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45197390..45223849)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene transforming growth factor beta regulator 4 Neighboring gene small nucleolar RNA, H/ACA box 5B Neighboring gene uncharacterized LOC107986736 Neighboring gene zinc finger protein 519 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of hepatic lipid content in extreme obesity.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adrenomedullin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to amylin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway involved in heart process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in adrenomedullin receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of adrenomedullin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of amylin receptor complex 3 IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with lysosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor activity-modifying protein 3
Names
CRLR activity-modifying protein 3
calcitonin receptor-like receptor activity modifying protein 3
receptor (G protein-coupled) activity modifying protein 3
receptor (calcitonin) activity modifying protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005856.3NP_005847.1  receptor activity-modifying protein 3 precursor

    See identical proteins and their annotated locations for NP_005847.1

    Status: REVIEWED

    Source sequence(s)
    BC053852, BP347072
    Consensus CDS
    CCDS5503.1
    UniProtKB/Swiss-Prot
    O60896
    UniProtKB/TrEMBL
    A4D2L1
    Related
    ENSP00000242249.4, ENST00000242249.8
    Conserved Domains (1) summary
    pfam04901
    Location:38145
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    45157778..45184250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715631.3XP_006715694.1  receptor activity-modifying protein 3 isoform X1

    Conserved Domains (1) summary
    pfam04901
    Location:149256
    RAMP; Receptor activity modifying family
  2. XM_017011666.1XP_016867155.1  receptor activity-modifying protein 3 isoform X2

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