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MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens (human) ]

Gene ID: 5608, updated on 3-Feb-2021

Summary

Official Symbol
MAP2K6provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 6provided by HGNC
Primary source
HGNC:HGNC:6846
See related
Ensembl:ENSG00000108984 MIM:601254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
Summary
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues See more
Orthologs
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Genomic context

See MAP2K6 in Genome Data Viewer
Location:
17q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (69414697..69553865)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (67410838..67550006)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 5 Neighboring gene uncharacterized LOC105371878 Neighboring gene uncharacterized LOC105371879 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 4 Neighboring gene uncharacterized LOC105371880 Neighboring gene uncharacterized LOC107985073 Neighboring gene long intergenic non-protein coding RNA 1483

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
GeneReviews: Not available
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
tat The association of HIV-1 Tat with MAP2K6 promoter leads to the activation of this kinase in immature dendritic cells and in monocyte-derived macrophages PubMed
tat MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages PubMed
tat SiRNA-mediated inhibition of MAP2K6 and MAP2K3 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage induced protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cellular response to sorbitol IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
ovulation cycle process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 6
Names
MAPK/ERK kinase 6
MAPKK 6
MEK 6
SAPK kinase 3
protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
stress-activated protein kinase kinase 3
NP_001317379.1
NP_002749.2
XP_005257573.1
XP_006722038.1
XP_011523328.1
XP_011523329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029437.2 RefSeqGene

    Range
    5001..144169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330450.2NP_001317379.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002546, BC037328
    Consensus CDS
    CCDS82194.1
    UniProtKB/TrEMBL
    A0A024R8K3
    Related
    ENSP00000467213.1, ENST00000589647.5
    Conserved Domains (1) summary
    cd06617
    Location:1277
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  2. NM_002758.4NP_002749.2  dual specificity mitogen-activated protein kinase kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_002749.2

    Status: REVIEWED

    Source sequence(s)
    AA932919, AC002546, BC012009, DB111443
    Consensus CDS
    CCDS11686.1
    UniProtKB/Swiss-Prot
    P52564
    UniProtKB/TrEMBL
    A8K3Y2
    Related
    ENSP00000468348.1, ENST00000590474.7
    Conserved Domains (1) summary
    cd06617
    Location:51333
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    69414697..69553865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257516.2XP_005257573.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

    See identical proteins and their annotated locations for XP_005257573.1

    UniProtKB/TrEMBL
    A0A024R8K3
    Conserved Domains (1) summary
    cd06617
    Location:1277
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  2. XM_011525027.3XP_011523329.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

    See identical proteins and their annotated locations for XP_011523329.1

    UniProtKB/TrEMBL
    A0A024R8K3
    Conserved Domains (1) summary
    cd06617
    Location:1277
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
  3. XM_011525026.2XP_011523328.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

    Conserved Domains (2) summary
    cd06617
    Location:54336
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:57317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_006721975.3XP_006722038.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

    See identical proteins and their annotated locations for XP_006722038.1

    UniProtKB/TrEMBL
    A0A024R8K3
    Conserved Domains (1) summary
    cd06617
    Location:1277
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031988.1: Suppressed sequence

    Description
    NM_031988.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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