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MAPK13 mitogen-activated protein kinase 13 [ Homo sapiens (human) ]

Gene ID: 5603, updated on 13-Mar-2020

Summary

Official Symbol
MAPK13provided by HGNC
Official Full Name
mitogen-activated protein kinase 13provided by HGNC
Primary source
HGNC:HGNC:6875
See related
Ensembl:ENSG00000156711 MIM:602899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta
Summary
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues See more
Orthologs

Genomic context

See MAPK13 in Genome Data Viewer
Location:
6p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (36130513..36144521)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36098261..36112301)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC105375034 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene ADP-sugar pyrophosphatase pseudogene Neighboring gene uncharacterized LOC102723648 Neighboring gene bromodomain and PHD finger containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed
Nef nef HIV-1 Nef involves MAPK13 in the regulation of IL6 expression PubMed
nef Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5 PubMed
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with p38delta PubMed
Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
Vpr vpr p38-MAPK13 (delta isoform of p38-MAPK) is involved in Vpr-mediated IL6 induction in astrocytes PubMed
vpr HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to anisomycin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to sodium arsenite IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to sorbitol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 13
Names
MAP kinase 13
MAP kinase p38 delta
mitogen-activated protein kinase p38 delta
stress-activated protein kinase 4
NP_002745.1
XP_024302259.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002754.5NP_002745.1  mitogen-activated protein kinase 13

    See identical proteins and their annotated locations for NP_002745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
    Source sequence(s)
    AF092535, DB335275, DB473379, DR006449, U93232, Z95152
    Consensus CDS
    CCDS4818.1
    UniProtKB/Swiss-Prot
    O15264
    UniProtKB/TrEMBL
    A0A024RD04
    Related
    ENSP00000211287.4, ENST00000211287.9
    Conserved Domains (1) summary
    cd07879
    Location:9351
    STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

RNA

  1. NR_072996.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC085196, DB335275, DB473379, DR006449, Z95152
    Related
    ENST00000373766.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    36130513..36144521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446491.1XP_024302259.1  mitogen-activated protein kinase 13 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
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