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Sfn stratifin [ Mus musculus (house mouse) ]

Gene ID: 55948, updated on 5-Jan-2023

Summary

Official Symbol
Sfnprovided by MGI
Official Full Name
stratifinprovided by MGI
Primary source
MGI:MGI:1891831
See related
Ensembl:ENSMUSG00000047281 AllianceGenome:MGI:1891831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Er; Mme1; Ywhas; 14-3-3
Summary
Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including establishment of skin barrier; positive regulation of protein export from nucleus; and regulation of epidermal cell division. Acts upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Sfn in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133327867..133329479, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133600556..133602168, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 2 Neighboring gene predicted gene, 42324 Neighboring gene zinc finger, DHHC domain containing 18 Neighboring gene predicted gene 13213

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
repeated epilation
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Radiation induced (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within keratinocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of epidermal cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within skin development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
14-3-3 protein sigma
Names
14-3-3 sigma protein
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018754.2NP_061224.2  14-3-3 protein sigma

    See identical proteins and their annotated locations for NP_061224.2

    Status: VALIDATED

    Source sequence(s)
    AA067103, AK169358, CX224942
    Consensus CDS
    CCDS18754.1
    UniProtKB/Swiss-Prot
    O70456, Q3TEZ1
    UniProtKB/TrEMBL
    A0A8C6G476
    Related
    ENSMUSP00000050374.4, ENSMUST00000057311.4
    Conserved Domains (1) summary
    cd10019
    Location:1242
    14-3-3_sigma; 14-3-3 sigma, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133327867..133329479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)