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SFN stratifin [ Homo sapiens (human) ]

Gene ID: 2810, updated on 7-Oct-2018

Summary

Official Symbol
SFNprovided by HGNC
Official Full Name
stratifinprovided by HGNC
Primary source
HGNC:HGNC:10773
See related
Ensembl:ENSG00000175793 MIM:601290; Vega:OTTHUMG00000004093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YWHAS
Summary
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
Orthologs

Genomic context

See SFN in Genome Data Viewer
Location:
1p36.11
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (26863138..26864457)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27189633..27190947)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 165, pseudogene Neighboring gene zinc finger DHHC-type containing 18 Neighboring gene GPN-loop GTPase 2 Neighboring gene G-patch domain containing 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase C inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
keratinization IEA
Inferred from Electronic Annotation
more info
 
keratinocyte development IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of epidermal cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
14-3-3 protein sigma
Names
epithelial cell marker protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006142.4NP_006133.1  14-3-3 protein sigma

    See identical proteins and their annotated locations for NP_006133.1

    Status: REVIEWED

    Source sequence(s)
    BC001550, BC023552
    Consensus CDS
    CCDS288.1
    UniProtKB/Swiss-Prot
    P31947
    Related
    ENSP00000340989.4, OTTHUMP00000004242, ENST00000339276.5
    Conserved Domains (1) summary
    cd10019
    Location:1242
    14-3-3_sigma; 14-3-3 sigma, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    26863138..26864457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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