Format

Send to:

Choose Destination

NKRF NFKB repressing factor [ Homo sapiens (human) ]

Gene ID: 55922, updated on 23-Nov-2021

Summary

Official Symbol
NKRFprovided by HGNC
Official Full Name
NFKB repressing factorprovided by HGNC
Primary source
HGNC:HGNC:19374
See related
Ensembl:ENSG00000186416 MIM:300440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRF; ITBA4
Summary
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in brain (RPKM 6.5), lymph node (RPKM 4.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NKRF in Genome Data Viewer
Location:
Xq24
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (119588337..119606424, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118722300..118740387, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene STING1 ER exit protein 1 Neighboring gene ubiquitin conjugating enzyme E2 A Neighboring gene septin 6 Neighboring gene microRNA 766 Neighboring gene sosondowah ankyrin repeat domain family member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify NFKappaB repressing factor (NKRF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify NFKappaB repressing factor (NKRF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify NFKappaB repressing factor (NKRF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify NFKappaB repressing factor (NKRF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human NFKB repressing factor (NKRF) at amino acid residues 21-22 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
NF-kappa-B-repressing factor
Names
transcription factor NRF

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016800.1 RefSeqGene

    Range
    5001..22547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017544.5NP_060014.3  NF-kappa-B-repressing factor

    Status: REVIEWED

    Source sequence(s)
    AA845622, AY208891, LPVO02000272
    Conserved Domains (4) summary
    cd02640
    Location:697756
    R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
    smart00443
    Location:643686
    G_patch; glycine rich nucleic binding domain
    pfam11952
    Location:38105
    XTBD; XRN-Two Binding Domain, XTBD
    cl00054
    Location:543605
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

RNA

  1. NR_163972.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA845622, AL539002, AY208891, BC047878, LPVO02000272
    Related
    ENST00000542113.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    119588337..119606424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001173487.1: Suppressed sequence

    Description
    NM_001173487.1: This RefSeq was removed because currently there is insufficient support for the protein.
  2. NM_001173488.1: Suppressed sequence

    Description
    NM_001173488.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center