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PRKG1 protein kinase cGMP-dependent 1 [ Homo sapiens (human) ]

Gene ID: 5592, updated on 22-May-2022

Summary

Official Symbol
PRKG1provided by HGNC
Official Full Name
protein kinase cGMP-dependent 1provided by HGNC
Primary source
HGNC:HGNC:9414
See related
Ensembl:ENSG00000185532 MIM:176894; AllianceGenome:HGNC:9414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha
Summary
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in endometrium (RPKM 4.7), lung (RPKM 4.4) and 22 other tissues See more
Orthologs
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Genomic context

See PRKG1 in Genome Data Viewer
Location:
10q11.23-q21.1
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (50990888..52298350)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (51839480..53144930)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (52750648..54058110)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene APOBEC1 complementation factor Neighboring gene uncharacterized LOC102724719 Neighboring gene MIX23 pseudogene 2 Neighboring gene microRNA 605 Neighboring gene Ras suppressor protein 1 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 685 Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene uncharacterized LOC124902425 Neighboring gene Sharpr-MPRA regulatory region 2630 Neighboring gene PRKG1 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 44 Neighboring gene dickkopf WNT signaling pathway inhibitor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Aortic aneurysm, familial thoracic 8
MedGen: C3809513 OMIM: 615436 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36117, MGC71944, DKFZp686K042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
 
enables cGMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cGMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
 
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-dependent protein kinase 1
Names
protein kinase, cGMP-dependent, regulatory, type I, beta
protein kinase, cGMP-dependent, type I
NP_001091982.1
NP_001361710.1
NP_001361711.1
NP_006249.1
XP_011538254.1
XP_016871902.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029982.1 RefSeqGene

    Range
    4738..1312200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1135

mRNA and Protein(s)

  1. NM_001098512.3NP_001091982.1  cGMP-dependent protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001091982.1

    Status: REVIEWED

    Source sequence(s)
    AL599933, AL731537, BC127090, BQ445850, BX097700, BX117079, BX952280, CD723759, D45864, DA646702, DA915933, DB138350, DC381245
    Consensus CDS
    CCDS44399.1
    UniProtKB/Swiss-Prot
    Q13976
    Related
    ENSP00000384200.4, ENST00000401604.8
    Conserved Domains (4) summary
    cd12085
    Location:249
    DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
    smart00133
    Location:621664
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00038
    Location:222326
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:366626
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
  2. NM_001374781.1NP_001361710.1  cGMP-dependent protein kinase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009986, AC022025, AC027118, AL928686
    Conserved Domains (2) summary
    smart00133
    Location:233276
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05572
    Location:1238
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
  3. NM_001374782.1NP_001361711.1  cGMP-dependent protein kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022025, AC022537, AC026228, AL157399, AL391378, AL731537
    Related
    ENSP00000363087.4, ENST00000373976.9
    Conserved Domains (3) summary
    smart00100
    Location:237310
    cNMP; Cyclic nucleotide-monophosphate binding domain
    cd12086
    Location:455
    DD_cGKI-beta; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
    cd00038
    Location:118227
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_006258.4NP_006249.1  cGMP-dependent protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_006249.1

    Status: REVIEWED

    Source sequence(s)
    AL599933, BC127090, BQ445850, BX097700, BX952280, CD723759, DA150150, DA646702, DA915933, DB138350
    Consensus CDS
    CCDS7244.1
    UniProtKB/Swiss-Prot
    Q13976
    Related
    ENSP00000363092.5, ENST00000373980.11
    Conserved Domains (4) summary
    cd12086
    Location:455
    DD_cGKI-beta; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
    smart00133
    Location:636679
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00038
    Location:237341
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:381641
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    50990888..52298350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016413.2XP_016871902.1  cGMP-dependent protein kinase 1 isoform X1

  2. XM_011539952.3XP_011538254.1  cGMP-dependent protein kinase 1 isoform X2

    Conserved Domains (3) summary
    cd12086
    Location:455
    DD_cGKI-beta; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
    COG0664
    Location:116218
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:237341
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    51839480..53144930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)