U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACTR10 actin related protein 10 [ Homo sapiens (human) ]

Gene ID: 55860, updated on 25-Nov-2025
Official Symbol
ACTR10provided by HGNC
Official Full Name
actin related protein 10provided by HGNC
Primary source
HGNC:HGNC:17372
See related
Ensembl:ENSG00000131966 MIM:619731; AllianceGenome:HGNC:17372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Arp10; Arp11; ACTR11; HARP11
Summary
Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in brain (RPKM 22.5), adrenal (RPKM 21.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ACTR10 in Genome Data Viewer
Location:
14q23.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (58200149..58235636)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (52407087..52442570)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58666867..58702354)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5794 Neighboring gene Sharpr-MPRA regulatory region 2203 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8440 Neighboring gene RNA, 7SL, cytoplasmic 598, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58711573-58712470 Neighboring gene tRNA-Lys (anticodon CTT) 1-1 Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene PSMA3 antisense RNA 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article
  2. Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Gisler SM, et al. Mol Cell Proteomics, 2008 Jul. PMID 18407958, Free PMC Article
  3. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. Bachmann-Gagescu R, et al. PLoS Genet, 2015 Oct. PMID 26485645, Free PMC Article
  4. Insights into the ubiquitin-proteasome system of human embryonic stem cells. Saez I, et al. Sci Rep, 2018 Mar 6. PMID 29511261, Free PMC Article
  5. Mapping the Genetic Landscape of Human Cells. Horlbeck MA, et al. Cell, 2018 Aug 9. PMID 30033366, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
actin-related protein 10
Names
actin related protein 10 homolog
actin-related protein 11

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018477.3 → NP_060947.1  actin-related protein 10

    See identical proteins and their annotated locations for NP_060947.1

    Status: VALIDATED

    Source sequence(s)
    AF220190, AL132989, CB135721
    Consensus CDS
    CCDS32090.1
    UniProtKB/Swiss-Prot
    Q9H9Y5, Q9NWY2, Q9NZ32
    UniProtKB/TrEMBL
    B2RDG9, Q53H79
    Related
    ENSP00000254286.4, ENST00000254286.9
    Conserved Domains (1) summary
    cl17037
    Location:14 → 388
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    58200149..58235636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536960.2 → XP_011535262.1  actin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    B2RDG9, Q53H79
    Related
    ENSP00000522646.1, ENST00000852587.1
    Conserved Domains (2) summary
    pfam00022
    Location:14 → 395
    Actin; Actin
    cl17037
    Location:12 → 389
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_011536961.2 → XP_011535263.1  actin-related protein 10 isoform X2

    UniProtKB/TrEMBL
    Q53H79
    Related
    ENSP00000522647.1, ENST00000852588.1
    Conserved Domains (2) summary
    pfam00022
    Location:14 → 376
    Actin; Actin
    cl17037
    Location:12 → 370
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_047431587.1 → XP_047287543.1  actin-related protein 10 isoform X3

    UniProtKB/TrEMBL
    Q86SY7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    52407087..52442570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376393.1 → XP_054232368.1  actin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    B2RDG9, Q53H79

  2. XM_054376394.1 → XP_054232369.1  actin-related protein 10 isoform X2

    UniProtKB/TrEMBL
    Q53H79

  3. XM_054376395.1 → XP_054232370.1  actin-related protein 10 isoform X3

    UniProtKB/TrEMBL
    Q86SY7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZ32.1 GenPept UniProtKB/Swiss-Prot:Q9NZ32

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous