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PPP2R2D protein phosphatase 2 regulatory subunit Bdelta [ Homo sapiens (human) ]

Gene ID: 55844, updated on 1-Jun-2020

Summary

Official Symbol
PPP2R2Dprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bdeltaprovided by HGNC
Primary source
HGNC:HGNC:23732
See related
Ensembl:ENSG00000175470 MIM:613992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55D; MDS026; B55delta
Expression
Ubiquitous expression in pancreas (RPKM 6.3), ovary (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R2D in Genome Data Viewer
Location:
10q26.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (131900934..131971535)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133747957..133770054)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene BCL2 interacting protein 3 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene uncharacterized LOC105378567 Neighboring gene dihydropyrimidinase like 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, delta (PPP2R2D), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
exit from mitosis ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Names
PP2A subunit B isoform B55-delta
PP2A subunit B isoform PR55-delta
PP2A subunit B isoform R2-delta
PP2A subunit B isoform delta
protein phosphatase 2 regulatory subunit B, delta
protein phosphatase 2, regulatory subunit B, delta isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291310.2NP_001278239.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform b

    See identical proteins and their annotated locations for NP_001278239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB040974, BC047379, BQ023669
    UniProtKB/Swiss-Prot
    Q66LE6
    UniProtKB/TrEMBL
    Q6IN90
    Conserved Domains (2) summary
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:17211
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_018461.5NP_060931.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a

    See identical proteins and their annotated locations for NP_060931.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB040974, BC047379, BQ023669
    Consensus CDS
    CCDS73224.1
    UniProtKB/Swiss-Prot
    Q66LE6
    Related
    ENSP00000399970.2, ENST00000455566.6
    Conserved Domains (2) summary
    COG5170
    Location:14448
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:3785
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_033191.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon and uses an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB040974, BC047379, BC060885, BQ023669

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    131900934..131971535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717914.3XP_006717977.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:3785
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:35333
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_002956987.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003656.1: Suppressed sequence

    Description
    NM_001003656.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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