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PPP2R2D protein phosphatase 2 regulatory subunit Bdelta [ Homo sapiens (human) ]

Gene ID: 55844, updated on 4-Dec-2022

Summary

Official Symbol
PPP2R2Dprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bdeltaprovided by HGNC
Primary source
HGNC:HGNC:23732
See related
Ensembl:ENSG00000175470 MIM:613992; AllianceGenome:HGNC:23732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55D; MDS026; B55delta
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in exit from mitosis and peptidyl-serine dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in pancreas (RPKM 6.3), ovary (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See PPP2R2D in Genome Data Viewer
Location:
10q26.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131901008..131971533)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (132840100..132900087)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133747955..133773338)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene Sharpr-MPRA regulatory region 4393 Neighboring gene uncharacterized LOC124902525 Neighboring gene BCL2 interacting protein 3 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene JAKMIP3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, delta (PPP2R2D), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in exit from mitosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Names
protein phosphatase 2 regulatory subunit B, delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291310.2NP_001278239.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform b

    See identical proteins and their annotated locations for NP_001278239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB040974, BC047379, BQ023669
    UniProtKB/Swiss-Prot
    Q66LE6
    UniProtKB/TrEMBL
    Q6IN90
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  2. NM_018461.5NP_060931.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a

    See identical proteins and their annotated locations for NP_060931.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB040974, BC047379, BQ023669
    Consensus CDS
    CCDS73224.1
    UniProtKB/Swiss-Prot
    Q66LE6, Q9P1Y7
    Related
    ENSP00000399970.2, ENST00000455566.6
    Conserved Domains (2) summary
    COG5170
    Location:14448
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:3785
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_033191.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon and uses an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB040974, BC047379, BC060885, BQ023669

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    131901008..131971533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717914.4XP_006717977.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:3785
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:35333
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_047425478.1XP_047281434.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X6

    UniProtKB/TrEMBL
    Q6IN90
  3. XM_047425475.1XP_047281431.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X6

    UniProtKB/TrEMBL
    Q6IN90
  4. XM_047425471.1XP_047281427.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

  5. XM_047425473.1XP_047281429.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3

  6. XM_047425472.1XP_047281428.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2

  7. XM_047425474.1XP_047281430.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5

  8. XM_047425476.1XP_047281432.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X6

    UniProtKB/TrEMBL
    Q6IN90
  9. XM_047425477.1XP_047281433.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X6

    UniProtKB/TrEMBL
    Q6IN90

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    132840100..132900087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003656.1: Suppressed sequence

    Description
    NM_001003656.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.