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SELENOS selenoprotein S [ Homo sapiens (human) ]

Gene ID: 55829, updated on 5-Aug-2022

Summary

Official Symbol
SELENOSprovided by HGNC
Official Full Name
selenoprotein Sprovided by HGNC
Primary source
HGNC:HGNC:30396
See related
Ensembl:ENSG00000131871 MIM:607918; AllianceGenome:HGNC:30396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015
Summary
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in testis (RPKM 27.4), colon (RPKM 26.5) and 25 other tissues See more
Orthologs
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Genomic context

See SELENOS in Genome Data Viewer
Location:
15q26.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101270809..101277485, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99025841..99032517, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101811014..101817690, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate synthase 1 Neighboring gene uncharacterized LOC107984727 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene SNRPA1 divergent transcript Neighboring gene proprotein convertase subtilisin/kexin type 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2553, MGC104346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ER overload response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ER overload response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of protein localization TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of glycogen biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of gluconeogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of nitric oxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
selenoprotein S
Names
VCP interacting membrane selenoprotein
VCP-interacting membrane protein
tanis
valosin-containing protein-interacting membrane protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013322.1 RefSeqGene

    Range
    5011..10305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018445.6NP_060915.2  selenoprotein S isoform 1

    See identical proteins and their annotated locations for NP_060915.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).
    Source sequence(s)
    AK097011, BC005840, BG829960
    Consensus CDS
    CCDS53979.1
    UniProtKB/Swiss-Prot
    Q9BQE4, Q9P0I6
    Related
    ENSP00000433541.1, ENST00000526049.6
    Conserved Domains (1) summary
    pfam06936
    Location:1187
    Selenoprotein_S; Selenoprotein S (SelS)
  2. NM_203472.3NP_982298.2  selenoprotein S isoform 2

    See identical proteins and their annotated locations for NP_982298.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).
    Source sequence(s)
    AC023024, BC107774, BG829960, DW430970
    UniProtKB/Swiss-Prot
    Q9BQE4
    UniProtKB/TrEMBL
    Q6GYA4
    Related
    ENSP00000381282.3, ENST00000398226.7
    Conserved Domains (1) summary
    pfam06936
    Location:1187
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    101270809..101277485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    99025841..99032517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)