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Selenos selenoprotein S [ Mus musculus (house mouse) ]

Gene ID: 109815, updated on 13-Oct-2022

Summary

Official Symbol
Selenosprovided by MGI
Official Full Name
selenoprotein Sprovided by MGI
Primary source
MGI:MGI:95994
See related
Ensembl:ENSMUSG00000075701 AllianceGenome:MGI:95994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4; H-4; H47; H-47; Sels; Vimp; Seps1; 1500011E07Rik
Summary
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in placenta adult (RPKM 73.8), testis adult (RPKM 50.8) and 28 other tissues See more
Orthologs
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Genomic context

See Selenos in Genome Data Viewer
Location:
7 C; 7 35.49 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65729397..65739153)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66079649..66089405)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene predicted gene, 51486 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene chondroitin sulfate synthase 1 Neighboring gene predicted gene, 23042 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nitric oxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to redox state ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
part_of Derlin-1-VIMP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Derlin-1-VIMP complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
selenoprotein S
Names
VCP-interacting membrane protein
minor histocompatibility antigen H47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348246.1NP_001335175.1  selenoprotein S isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation from an alternate start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC124695, AI836862, AK005204
    UniProtKB/Swiss-Prot
    Q9BCZ4
    Conserved Domains (1) summary
    pfam06936
    Location:3165
    Selenoprotein_S; Selenoprotein S (SelS)
  2. NM_024439.3NP_077759.3  selenoprotein S isoform 1

    See identical proteins and their annotated locations for NP_077759.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI836862, AK005204, BY335100
    Consensus CDS
    CCDS39977.1
    UniProtKB/Swiss-Prot
    Q9BCZ4, Q9DB55
    Related
    ENSMUSP00000099301.7, ENSMUST00000101801.8
    Conserved Domains (1) summary
    pfam06936
    Location:1188
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    65729397..65739153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)