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DCAF6 DDB1 and CUL4 associated factor 6 [ Homo sapiens (human) ]

Gene ID: 55827, updated on 28-Sep-2022

Summary

Official Symbol
DCAF6provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 6provided by HGNC
Primary source
HGNC:HGNC:30002
See related
Ensembl:ENSG00000143164 MIM:610494; AllianceGenome:HGNC:30002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik
Summary
The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]
Expression
Broad expression in testis (RPKM 48.7), heart (RPKM 45.3) and 24 other tissues See more
Orthologs
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Genomic context

See DCAF6 in Genome Data Viewer
Location:
1q24.2
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167863576..168075836)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167287705..167427301)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167905477..168045074)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon AGG) 2-1 Neighboring gene myelin protein zero like 1 Neighboring gene adenylate cyclase 10 Neighboring gene Sharpr-MPRA regulatory region 4419 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene microRNA 1255b-2 Neighboring gene Sharpr-MPRA regulatory region 7850 Neighboring gene GCSH pseudogene 5 Neighboring gene G protein-coupled receptor 161 Neighboring gene Sharpr-MPRA regulatory region 11959

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23798

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 6
Names
IQ motif and WD repeat-containing protein 1
IQ motif and WD repeats 1
androgen receptor complex-associated protein
nuclear receptor interaction protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053062.2 RefSeqGene

    Range
    78109..217262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017977.3NP_001017977.1  DDB1- and CUL4-associated factor 6 isoform b

    See identical proteins and their annotated locations for NP_001017977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons and a downstream single exon in the CDS compared to variant 3. The reading frame is not changed and the resulting isoform (b) lacks two internal segments compared to isoform c.
    Source sequence(s)
    AY766164, CA310484, DA128283
    Consensus CDS
    CCDS30933.1
    UniProtKB/Swiss-Prot
    Q58WW2, Q8TB19
    Related
    ENSP00000311949.6, ENST00000312263.10
    Conserved Domains (3) summary
    COG2319
    Location:42281
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001198956.2NP_001185885.1  DDB1- and CUL4-associated factor 6 isoform c

    See identical proteins and their annotated locations for NP_001185885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AF116725, CA310484, DA128283
    Consensus CDS
    CCDS55657.1
    UniProtKB/Swiss-Prot
    Q58WW2
    Related
    ENSP00000356814.3, ENST00000367840.4
    Conserved Domains (3) summary
    COG2319
    Location:42281
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001198957.2NP_001185886.1  DDB1- and CUL4-associated factor 6 isoform d

    See identical proteins and their annotated locations for NP_001185886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS compared to variant 3. The resulting isoform (d) lacks an internal segment compared to isoform c.
    Source sequence(s)
    AF116725, AK297847, CA310484, DA128283
    Consensus CDS
    CCDS55658.1
    UniProtKB/Swiss-Prot
    Q58WW2
    Related
    ENSP00000396238.2, ENST00000432587.6
    Conserved Domains (3) summary
    COG2319
    Location:48250
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:66107
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48261
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001349773.2NP_001336702.1  DDB1- and CUL4-associated factor 6 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform e.
    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
    Conserved Domains (3) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:394743
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  5. NM_001349774.2NP_001336703.1  DDB1- and CUL4-associated factor 6 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 7-9, encodes isoform f.
    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:142539
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  6. NM_001349775.2NP_001336704.1  DDB1- and CUL4-associated factor 6 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 6, 8, and 9, encodes isoform f.
    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:142539
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  7. NM_001349776.2NP_001336705.1  DDB1- and CUL4-associated factor 6 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 6, 7, and 9, encodes isoform f.
    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:142539
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  8. NM_001349777.2NP_001336706.1  DDB1- and CUL4-associated factor 6 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 6-8, encodes isoform f.
    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:142539
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  9. NM_001349778.2NP_001336707.1  DDB1- and CUL4-associated factor 6 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform g.
    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
    Conserved Domains (3) summary
    PRK14949
    Location:142519
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. NM_001349779.2NP_001336708.1  DDB1- and CUL4-associated factor 6 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform g.
    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
    Conserved Domains (3) summary
    PRK14949
    Location:142519
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. NM_001349780.2NP_001336709.1  DDB1- and CUL4-associated factor 6 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform g.
    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
    Conserved Domains (3) summary
    PRK14949
    Location:142519
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. NM_001393650.1NP_001380579.1  DDB1- and CUL4-associated factor 6 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
    Conserved Domains (3) summary
    PRK14949
    Location:289666
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. NM_001393651.1NP_001380580.1  DDB1- and CUL4-associated factor 6 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
    Conserved Domains (3) summary
    PRK14949
    Location:289686
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. NM_018442.4NP_060912.2  DDB1- and CUL4-associated factor 6 isoform a

    See identical proteins and their annotated locations for NP_060912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two in-frame exons in the CDS compared to variant 3. The resulting isoform (a) lacks two internal segments compared to isoform c.
    Source sequence(s)
    AF116725, AL136738, CA310484, DA128283
    Consensus CDS
    CCDS1267.2
    UniProtKB/Swiss-Prot
    Q58WW2
    Related
    ENSP00000356817.3, ENST00000367843.7
    Conserved Domains (3) summary
    COG2319
    Location:42281
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_146228.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031287, AL033531, AL033532, Z97876
  2. NR_146229.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876
  3. NR_146230.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031287, AL033531, AL033532, KF455056, Z97876

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167863576..168075836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425194.1XP_047281150.1  DDB1- and CUL4-associated factor 6 isoform X1

  2. XM_017001779.3XP_016857268.1  DDB1- and CUL4-associated factor 6 isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:247596
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. XM_047425193.1XP_047281149.1  DDB1- and CUL4-associated factor 6 isoform X1

  4. XM_024448371.2XP_024304139.1  DDB1- and CUL4-associated factor 6 isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:247596
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  5. XM_047425198.1XP_047281154.1  DDB1- and CUL4-associated factor 6 isoform X2

  6. XM_024448374.2XP_024304142.1  DDB1- and CUL4-associated factor 6 isoform X4

    Conserved Domains (3) summary
    PRK14949
    Location:142519
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_024448373.2XP_024304141.1  DDB1- and CUL4-associated factor 6 isoform X3

    Conserved Domains (3) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26247
    Location:142519
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  8. XM_024448375.2XP_024304143.1  DDB1- and CUL4-associated factor 6 isoform X4

    Conserved Domains (3) summary
    PRK14949
    Location:142519
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    167287705..167427301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)