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Anticancer Res. 2013 Nov;33(11):4811-9.

Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer.

Author information

1
2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 Japan. hsasano@patholo2.med.tohoku.ac.jp.

Abstract

BACKGROUND:

Androgen receptors (ARs) are expressed in many breast cancer cells, but the mechanism of action of androgens is not as well-characterized as in other cell types. The study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer.

MATERIALS AND METHODS:

We attempted to identify microRNAs induced by dihydrotestosterone in an AR-positive cell line. We examined a possible correlation among microRNAs, target genes, and ARs in breast cancer tissues using immunohistochemistry and laser capture microscopy.

RESULTS:

Our analysis demonstrated that miR-363 and its possible target IQ motif and WD repeats-1 (IQWD1) are involved in a microRNA-mRNA pathway related to the mechanism of action of androgens. Our analyses showed that a high tumor level of IQWD1 in patients with breast cancer was significantly associated with adverse clinical outcomes.

CONCLUSION:

Our findings indicated that the recruitment of IQWD1 to ARs may be a prerequisite for the growth stimulation by androgens through ARs in breast cancer cells.

KEYWORDS:

Breast cancer; IQWD1; androgen; microRNA

PMID:
24222117
[Indexed for MEDLINE]
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