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PECR peroxisomal trans-2-enoyl-CoA reductase [ Homo sapiens (human) ]

Gene ID: 55825, updated on 9-Dec-2018

Summary

Official Symbol
PECRprovided by HGNC
Official Full Name
peroxisomal trans-2-enoyl-CoA reductaseprovided by HGNC
Primary source
HGNC:HGNC:18281
See related
Ensembl:ENSG00000115425 MIM:605843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TERP; DCRRP; PVIARL; HPDHASE; SDR29C1; HSA250303
Expression
Broad expression in liver (RPKM 14.1), fat (RPKM 7.2) and 15 other tissues See more
Orthologs

Genomic context

See PECR in Genome Data Viewer
Location:
2q35
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (216031656..216081843, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216903111..216946539, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373870 Neighboring gene melanoregulin Neighboring gene transmembrane protein 169 Neighboring gene Sharpr-MPRA regulatory regions 7837 and 8351 Neighboring gene X-ray repair cross complementing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
trans-2-enoyl-CoA reductase (NADPH) activity EXP
Inferred from Experiment
more info
PubMed 
trans-2-enoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-2-enoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
fatty acid alpha-oxidation TAS
Traceable Author Statement
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
phytol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phytol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peroxisomal membrane TAS
Traceable Author Statement
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal trans-2-enoyl-CoA reductase
Names
2,4-dienoyl-CoA reductase-related protein
DCR-RP
pVI-ARL
putative short chain alcohol dehydrogenase
short chain dehydrogenase/reductase family 29C member 1
NP_060911.2
XP_024308766.1
XP_024308767.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018441.6NP_060911.2  peroxisomal trans-2-enoyl-CoA reductase

    See identical proteins and their annotated locations for NP_060911.2

    Status: VALIDATED

    Source sequence(s)
    AC010686, AF212234, BU151224
    Consensus CDS
    CCDS33375.1
    UniProtKB/Swiss-Prot
    Q9BY49
    Related
    ENSP00000265322.7, ENST00000265322.7
    Conserved Domains (1) summary
    cd05369
    Location:16267
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    216031656..216081843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452998.1XP_024308766.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

    Conserved Domains (1) summary
    cl25409
    Location:1130
    SDR; Short-chain dehydrogenases/reductases (SDR)
  2. XM_024452999.1XP_024308767.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

    Conserved Domains (1) summary
    cl25409
    Location:2121
    SDR; Short-chain dehydrogenases/reductases (SDR)

RNA

  1. XR_001738847.2 RNA Sequence

  2. XR_001738848.2 RNA Sequence

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