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PECR peroxisomal trans-2-enoyl-CoA reductase [ Homo sapiens (human) ]

Gene ID: 55825, updated on 23-Nov-2023

Summary

Official Symbol
PECRprovided by HGNC
Official Full Name
peroxisomal trans-2-enoyl-CoA reductaseprovided by HGNC
Primary source
HGNC:HGNC:18281
See related
Ensembl:ENSG00000115425 MIM:605843; AllianceGenome:HGNC:18281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TERP; DCRRP; PVIARL; HPDHASE; SDR29C1; HSA250303
Summary
Enables signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in phytol metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 14.1), fat (RPKM 7.2) and 15 other tissues See more
Orthologs
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Genomic context

See PECR in Genome Data Viewer
Location:
2q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216029088..216081809, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216514519..216567213, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216903111..216946532, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 607 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17076 Neighboring gene uncharacterized LOC105373870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216786644-216787283 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216787284-216787924 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:216792334-216792860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17078 Neighboring gene melanoregulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216877329-216878096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216973795-216974416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17089 Neighboring gene Sharpr-MPRA regulatory regions 7837 and 8351 Neighboring gene transmembrane protein 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17092 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:217020960-217022159 Neighboring gene X-ray repair cross complementing 5 Neighboring gene DNA polymerase eta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables trans-2-enoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phytol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phytol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal trans-2-enoyl-CoA reductase
Names
2,4-dienoyl-CoA reductase-related protein
DCR-RP
pVI-ARL
putative short chain alcohol dehydrogenase
short chain dehydrogenase/reductase family 29C member 1
NP_060911.2
XP_047301062.1
XP_047301063.1
XP_047301064.1
XP_054198979.1
XP_054198980.1
XP_054198981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018441.6NP_060911.2  peroxisomal trans-2-enoyl-CoA reductase

    See identical proteins and their annotated locations for NP_060911.2

    Status: VALIDATED

    Source sequence(s)
    AC010686, AF212234, BU151224
    Consensus CDS
    CCDS33375.1
    UniProtKB/Swiss-Prot
    B2RE42, Q53TC4, Q6IAK9, Q9BY49, Q9NRD4, Q9NY60, Q9P1A4
    Related
    ENSP00000265322.7, ENST00000265322.8
    Conserved Domains (1) summary
    cd05369
    Location:16267
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216029088..216081809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445108.1XP_047301064.1  peroxisomal trans-2-enoyl-CoA reductase isoform X3

  2. XM_047445107.1XP_047301063.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

    UniProtKB/TrEMBL
    B4DJS2
    Related
    ENSP00000395512.1, ENST00000442122.5
  3. XM_047445106.1XP_047301062.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

RNA

  1. XR_007078553.1 RNA Sequence

  2. XR_007078552.1 RNA Sequence

  3. XR_001738847.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    216514519..216567213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343006.1XP_054198981.1  peroxisomal trans-2-enoyl-CoA reductase isoform X3

  2. XM_054343005.1XP_054198980.1  peroxisomal trans-2-enoyl-CoA reductase isoform X2

    UniProtKB/TrEMBL
    B4DJS2
  3. XM_054343004.1XP_054198979.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

RNA

  1. XR_008486457.1 RNA Sequence

  2. XR_008486456.1 RNA Sequence

  3. XR_008486455.1 RNA Sequence