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DDX28 DEAD-box helicase 28 [ Homo sapiens (human) ]

Gene ID: 55794, updated on 2-Oct-2018

Summary

Official Symbol
DDX28provided by HGNC
Official Full Name
DEAD-box helicase 28provided by HGNC
Primary source
HGNC:HGNC:17330
See related
Ensembl:ENSG00000182810 MIM:607618; Vega:OTTHUMG00000137549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDDX28
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See DDX28 in Genome Data Viewer
Location:
16q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (68021274..68023867, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68055177..68057770, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 359, pseudogene Neighboring gene DPEP2 neighbor Neighboring gene dihydrouridine synthase 2 Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA knockdown of DDX28 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag siRNA knockdown of DDX28 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial large ribosomal subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX28
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28
mitochondrial DEAD box protein 28
mitochondrial DEAD-box polypeptide 28
NP_060850.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018380.3NP_060850.2  probable ATP-dependent RNA helicase DDX28

    See identical proteins and their annotated locations for NP_060850.2

    Status: REVIEWED

    Source sequence(s)
    AK002144, BM671594, CF993871, DA159162
    Consensus CDS
    CCDS10858.1
    UniProtKB/Swiss-Prot
    Q9NUL7
    Related
    ENSP00000332340.5, OTTHUMP00000174854, ENST00000332395.6, OTTHUMT00000268883
    Conserved Domains (3) summary
    PRK01297
    Location:27538
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    pfam00271
    Location:376492
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:128343
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    68021274..68023867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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