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FGD6 FYVE, RhoGEF and PH domain containing 6 [ Homo sapiens (human) ]

Gene ID: 55785, updated on 11-Sep-2019

Summary

Official Symbol
FGD6provided by HGNC
Official Full Name
FYVE, RhoGEF and PH domain containing 6provided by HGNC
Primary source
HGNC:HGNC:21740
See related
Ensembl:ENSG00000180263 MIM:613520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFYVE24
Expression
Ubiquitous expression in skin (RPKM 3.9), gall bladder (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See FGD6 in Genome Data Viewer
Location:
12q22
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (95076749..95217467, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95470525..95611240, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene nuclear receptor subfamily 2 group C member 1 Neighboring gene uncharacterized LOC112268099 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene ribosomal protein L14 pseudogene 4 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene RNA, U6 small nuclear 808, pseudogene Neighboring gene chromobox 3 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of FYVE, RhoGEF and PH domain containing 6 (FGD6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
FYVE, RhoGEF and PH domain-containing protein 6
Names
zinc finger FYVE domain-containing protein 24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018351.4NP_060821.3  FYVE, RhoGEF and PH domain-containing protein 6

    See identical proteins and their annotated locations for NP_060821.3

    Status: VALIDATED

    Source sequence(s)
    AC011598, AC127165, AK124904, AK128492
    Consensus CDS
    CCDS31878.1
    UniProtKB/Swiss-Prot
    Q6ZV73
    Related
    ENSP00000344446.4, ENST00000343958.9
    Conserved Domains (5) summary
    cd13237
    Location:13361424
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15793
    Location:10771199
    PH1_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin Homology (PH) domain
    cd15743
    Location:12171277
    FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
    pfam00169
    Location:13361426
    PH; PH domain
    pfam00621
    Location:8751059
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    95076749..95217467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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