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PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta [ Homo sapiens (human) ]

Gene ID: 5577, updated on 3-May-2020

Summary

Official Symbol
PRKAR2Bprovided by HGNC
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9392
See related
Ensembl:ENSG00000005249 MIM:176912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKAR2; RII-BETA
Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 215.5), adrenal (RPKM 38.6) and 7 other tissues See more
Orthologs

Genomic context

See PRKAR2B in Genome Data Viewer
Location:
7q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (107044705..107161811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106685178..106802256)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.4048 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4050 Neighboring gene PRKAR2B antisense RNA 1 Neighboring gene HMG-box transcription factor 1 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide interaction study of smoking and bladder cancer risk.
NHGRI GWA Catalog
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
NHGRI GWA Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
renal water homeostasis TAS
Traceable Author Statement
more info
 
response to clozapine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary base TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase type II-beta regulatory subunit
Names
H_RG363E19.2
WUGSC:H_RG363E19.2
cAMP-dependent protein kinase type II-beta regulatory chain
protein kinase, cAMP-dependent, regulatory subunit type II beta
protein kinase, cAMP-dependent, regulatory, type II, beta
NP_002727.2
XP_011514700.1
XP_024302604.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002736.3NP_002727.2  cAMP-dependent protein kinase type II-beta regulatory subunit

    See identical proteins and their annotated locations for NP_002727.2

    Status: REVIEWED

    Source sequence(s)
    AC006387, AK128639, AL559918, BQ022817, CA405423, CF593944, M31158
    Consensus CDS
    CCDS5740.1
    UniProtKB/Swiss-Prot
    P31323
    UniProtKB/TrEMBL
    A0A024R712, B3KY43
    Related
    ENSP00000265717.4, ENST00000265717.5
    Conserved Domains (3) summary
    cd12104
    Location:343
    DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:270385
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:154267
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    107044705..107161811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516398.1XP_011514700.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1

    Conserved Domains (3) summary
    cd12104
    Location:343
    DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:242357
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:248368
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_024446836.1XP_024302604.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X2

    Conserved Domains (1) summary
    cd00038
    Location:114234
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p13 PATCHES

    Range
    2504..7333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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