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NECAP2 NECAP endocytosis associated 2 [ Homo sapiens (human) ]

Gene ID: 55707, updated on 21-Dec-2019

Summary

Official Symbol
NECAP2provided by HGNC
Official Full Name
NECAP endocytosis associated 2provided by HGNC
Primary source
HGNC:HGNC:25528
See related
Ensembl:ENSG00000157191 MIM:611624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in lymph node (RPKM 34.8), spleen (RPKM 33.6) and 25 other tissues See more
Orthologs

Genomic context

See NECAP2 in Genome Data Viewer
Location:
1p36.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (16440672..16460090)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16767167..16786585)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene spermatogenesis associated 21 Neighboring gene long intergenic non-protein coding RNA 1772 Neighboring gene CROCC pseudogene 3 Neighboring gene RNA, U1 small nuclear 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10420

Gene Ontology Provided by GOA

Process Evidence Code Pubs
endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
clathrin vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adaptin ear-binding coat-associated protein 2
Names
adaptin-ear-binding coat-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047165.1 RefSeqGene

    Range
    5053..24407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145277.1NP_001138749.1  adaptin ear-binding coat-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001138749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region compared to variant 1 that causes a frameshift. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK023545, BC018914, BM751287, BQ005870, BU676615
    Consensus CDS
    CCDS44066.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    Related
    ENSP00000391942.2, ENST00000443980.6
    Conserved Domains (1) summary
    pfam07933
    Location:6162
    DUF1681; Protein of unknown function (DUF1681)
  2. NM_001145278.1NP_001138750.1  adaptin ear-binding coat-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AK302227, BC018914, BM751287, BQ005870, BU676615
    Consensus CDS
    CCDS44067.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    Related
    ENSP00000407091.2, ENST00000457722.6
    Conserved Domains (1) summary
    pfam07933
    Location:6136
    DUF1681; Protein of unknown function (DUF1681)
  3. NM_018090.5NP_060560.1  adaptin ear-binding coat-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC018914, BM751287, BQ005870
    Consensus CDS
    CCDS173.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    UniProtKB/TrEMBL
    A0A024QZ81
    Related
    ENSP00000338746.5, ENST00000337132.10
    Conserved Domains (2) summary
    pfam07933
    Location:6162
    DUF1681; Protein of unknown function (DUF1681)
    cl26247
    Location:169243
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    16440672..16460090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001721.1XP_016857210.1  adaptin ear-binding coat-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    B4DUR7
    Conserved Domains (1) summary
    pfam07933
    Location:6162
    DUF1681; Protein of unknown function (DUF1681)
  2. XM_011541767.2XP_011540069.1  adaptin ear-binding coat-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam07933
    Location:2109
    DUF1681; Protein of unknown function (DUF1681)

RNA

  1. XR_002957108.1 RNA Sequence

  2. XR_002957109.1 RNA Sequence

  3. XR_001737295.1 RNA Sequence

  4. XR_001737296.1 RNA Sequence

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