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SLC30A6 solute carrier family 30 member 6 [ Homo sapiens (human) ]

Gene ID: 55676, updated on 5-Aug-2018

Summary

Official Symbol
SLC30A6provided by HGNC
Official Full Name
solute carrier family 30 member 6provided by HGNC
Primary source
HGNC:HGNC:19305
See related
Ensembl:ENSG00000152683 MIM:611148; Vega:OTTHUMG00000128456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT6; MST103; MSTP103
Summary
This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.9), urinary bladder (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See SLC30A6 in Genome Data Viewer
Location:
2p22.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (32165841..32224379)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32390910..32449181)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dpy-30, histone methyltransferase complex regulatory subunit Neighboring gene spastin Neighboring gene DEAD-box helicase 50 pseudogene 1 Neighboring gene RNA, U6 small nuclear 647, pseudogene Neighboring gene NLR family CARD domain containing 4 Neighboring gene Yip1 domain family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31101, MGC45055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc transporter 6
Names
solute carrier family 30 (zinc transporter), member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193513.2NP_001180442.1  zinc transporter 6 isoform 1

    See identical proteins and their annotated locations for NP_001180442.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA594503, AK055663, BC032525, BC066903, BG527678, DB469378
    Consensus CDS
    CCDS54341.1
    UniProtKB/Swiss-Prot
    Q6NXT4
    Related
    ENSP00000368648.2, OTTHUMP00000201174, ENST00000379343.6, OTTHUMT00000325226
    Conserved Domains (2) summary
    COG1230
    Location:113371
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:113295
    Cation_efflux; Cation efflux family
  2. NM_001193514.2NP_001180443.1  zinc transporter 6 isoform 3

    See identical proteins and their annotated locations for NP_001180443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AA594503, AK055663, BC032525, BG527678, DB469378, EF560719
    Consensus CDS
    CCDS54342.1
    UniProtKB/Swiss-Prot
    Q6NXT4
    Related
    ENSP00000399005.1, ENST00000435660.5
    Conserved Domains (1) summary
    pfam01545
    Location:43255
    Cation_efflux; Cation efflux family
  3. NM_001193515.2NP_001180444.1  zinc transporter 6 isoform 4

    See identical proteins and their annotated locations for NP_001180444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AA594503, AK304225, AL121653, DB469378
    Consensus CDS
    CCDS54343.1
    UniProtKB/Swiss-Prot
    Q6NXT4
    Related
    ENSP00000349563.4, ENST00000357055.7
    Conserved Domains (2) summary
    COG1230
    Location:26302
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:14226
    Cation_efflux; Cation efflux family
  4. NM_001330476.1NP_001317405.1  zinc transporter 6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA594503, AL121653, AL832755, DB469378
    Consensus CDS
    CCDS82434.1
    UniProtKB/TrEMBL
    B5MCR8
    Related
    ENSP00000384041.1, ENST00000406369.2
    Conserved Domains (1) summary
    COG1230
    Location:4257
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
  5. NM_001330477.1NP_001317406.1  zinc transporter 6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AA594503, AK096672, AL121653, DB469378
    UniProtKB/TrEMBL
    B3KU87
    Conserved Domains (1) summary
    cl25570
    Location:5134
    Cation_efflux; Cation efflux family
  6. NM_001330478.1NP_001317407.1  zinc transporter 6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AA594503, AK127716, AL121653, DB469378
    UniProtKB/TrEMBL
    B3KU87
    Conserved Domains (1) summary
    cl25570
    Location:5134
    Cation_efflux; Cation efflux family
  7. NM_001330479.1NP_001317408.1  zinc transporter 6 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL121653, AL121658
    Conserved Domains (2) summary
    COG1230
    Location:6282
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:6206
    Cation_efflux; Cation efflux family
  8. NM_017964.4NP_060434.2  zinc transporter 6 isoform 2

    See identical proteins and their annotated locations for NP_060434.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA594503, AK055663, BC032525, BG527678, DB469378
    Consensus CDS
    CCDS1780.1
    UniProtKB/Swiss-Prot
    Q6NXT4
    Related
    ENSP00000282587.5, OTTHUMP00000158572, ENST00000282587.9, OTTHUMT00000250254
    Conserved Domains (2) summary
    COG1230
    Location:55331
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:43255
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    32165841..32224379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004466.2XP_016859955.1  zinc transporter 6 isoform X8

  2. XM_024452981.1XP_024308749.1  zinc transporter 6 isoform X2

    Conserved Domains (1) summary
    COG1230
    Location:4257
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
  3. XM_011532959.3XP_011531261.1  zinc transporter 6 isoform X1

    Conserved Domains (2) summary
    COG1230
    Location:113348
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:113295
    Cation_efflux; Cation efflux family
  4. XM_011532963.3XP_011531265.1  zinc transporter 6 isoform X3

    Conserved Domains (2) summary
    COG1230
    Location:113331
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:113295
    Cation_efflux; Cation efflux family
  5. XM_017004465.2XP_016859954.1  zinc transporter 6 isoform X6

  6. XM_017004463.1XP_016859952.1  zinc transporter 6 isoform X4

  7. XM_017004464.2XP_016859953.1  zinc transporter 6 isoform X5

  8. XM_017004462.2XP_016859951.1  zinc transporter 6 isoform X2

    UniProtKB/TrEMBL
    B5MCR8
    Related
    OTTHUMP00000201177
    Conserved Domains (1) summary
    COG1230
    Location:4257
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
  9. XM_024452982.1XP_024308750.1  zinc transporter 6 isoform X7

    Conserved Domains (1) summary
    cl25570
    Location:5134
    Cation_efflux; Cation efflux family
  10. XM_006712048.4XP_006712111.1  zinc transporter 6 isoform X7

    See identical proteins and their annotated locations for XP_006712111.1

    UniProtKB/TrEMBL
    B3KU87
    Conserved Domains (1) summary
    cl25570
    Location:5134
    Cation_efflux; Cation efflux family
  11. XM_011532962.3XP_011531264.1  zinc transporter 6 isoform X2

    See identical proteins and their annotated locations for XP_011531264.1

    UniProtKB/TrEMBL
    B5MCR8
    Conserved Domains (1) summary
    COG1230
    Location:4257
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
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