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URGCP upregulator of cell proliferation [ Homo sapiens (human) ]

Gene ID: 55665, updated on 3-May-2020

Summary

Official Symbol
URGCPprovided by HGNC
Official Full Name
upregulator of cell proliferationprovided by HGNC
Primary source
HGNC:HGNC:30890
See related
Ensembl:ENSG00000106608 MIM:610337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URG4
Summary
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in adrenal (RPKM 9.7), kidney (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See URGCP in Genome Data Viewer
Location:
7p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (43875894..43926411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43915485..43965996, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724946 Neighboring gene Sharpr-MPRA regulatory region 4653 Neighboring gene URGCP-MRPS24 readthrough Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene tubulin gamma 1 pseudogene Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) Neighboring gene RNA polymerase II subunit J4, pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member E1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough URGCP-MRPS24

Readthrough gene: URGCP-MRPS24, Included gene: MRPS24

Homology

Clone Names

  • DKFZp666G166, DKFZp686O0457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
up-regulator of cell proliferation
Names
HBV X protein up-regulated gene 4 protein
HBxAg up-regulated gene 4 protein
up-regulated gene 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077663.3NP_001071131.1  up-regulator of cell proliferation isoform 3

    See identical proteins and their annotated locations for NP_001071131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
    Source sequence(s)
    AB040940, AK000661, BX648505
    Consensus CDS
    CCDS47578.1
    UniProtKB/Swiss-Prot
    Q8TCY9
    Related
    ENSP00000396918.1, ENST00000453200.5
    Conserved Domains (1) summary
    cl21455
    Location:692792
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001077664.2NP_001071132.1  up-regulator of cell proliferation isoform 2

    See identical proteins and their annotated locations for NP_001071132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 3. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AB040940, AK000661, DC336174
    Consensus CDS
    CCDS43572.1
    UniProtKB/Swiss-Prot
    Q8TCY9
    Related
    ENSP00000336872.6, ENST00000336086.10
    Conserved Domains (1) summary
    cl21455
    Location:649749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001290075.1NP_001277004.1  up-regulator of cell proliferation isoform 2

    See identical proteins and their annotated locations for NP_001277004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 3. The 5'-most initiation codon, as used in variant 3, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (2) with a shorter N-terminus compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AB040940, AC004985, AK000661, CR749398, DA494692
    Consensus CDS
    CCDS43572.1
    UniProtKB/Swiss-Prot
    Q8TCY9
    Related
    ENSP00000392136.1, ENST00000443736.5
    Conserved Domains (1) summary
    cl21455
    Location:649749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001290076.1NP_001277005.1  up-regulator of cell proliferation isoform 2

    See identical proteins and their annotated locations for NP_001277005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 3. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AB040940, AK000661, AK302459, AK314339
    Consensus CDS
    CCDS43572.1
    UniProtKB/Swiss-Prot
    Q8TCY9
    UniProtKB/TrEMBL
    B2RAT5, B7Z7T1
    Conserved Domains (1) summary
    cl21455
    Location:649749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_017920.4NP_060390.3  up-regulator of cell proliferation isoform 1

    See identical proteins and their annotated locations for NP_060390.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. The resulting protein (isoform 1) is shorter, compared to isoform 3.
    Source sequence(s)
    AB040940, AC004985, AK000661, AK314339, DA494692
    Consensus CDS
    CCDS47577.1
    UniProtKB/Swiss-Prot
    Q8TCY9
    UniProtKB/TrEMBL
    A0A024RA74, B2RAT5
    Related
    ENSP00000384955.3, ENST00000402306.7
    Conserved Domains (1) summary
    cl21455
    Location:683783
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    43875894..43926411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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