Format

Send to:

Choose Destination

NHP2 NHP2 ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 55651, updated on 5-Jul-2020

Summary

Official Symbol
NHP2provided by HGNC
Official Full Name
NHP2 ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:14377
See related
Ensembl:ENSG00000145912 MIM:606470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKCB2; NHP2P; NOLA2
Summary
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in esophagus (RPKM 36.2), brain (RPKM 32.1) and 25 other tissues See more
Orthologs

Genomic context

See NHP2 in Genome Data Viewer
Location:
5q35.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (178149463..178153960, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177576464..177580961, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377754 Neighboring gene NEDD4 binding protein 3 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene germ cell-less 2, spermatogenesis associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human NHP2 ribonucleoprotein homolog (yeast) (NHP2) at amino acid residues 27-28 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
box H/ACA snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box H/ACA snoRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cleavage involved in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA pseudouridine synthesis ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA pseudouridine synthesis TAS
Traceable Author Statement
more info
 
snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
box H/ACA scaRNP complex TAS
Traceable Author Statement
more info
PubMed 
box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box H/ACA snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
box H/ACA snoRNP complex TAS
Traceable Author Statement
more info
PubMed 
box H/ACA telomerase RNP complex IDA
Inferred from Direct Assay
more info
PubMed 
box H/ACA telomerase RNP complex TAS
Traceable Author Statement
more info
PubMed 
nuclear chromosome, telomeric region HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
small nucleolar ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
telomerase holoenzyme complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
H/ACA ribonucleoprotein complex subunit 2
Names
NHP2 ribonucleoprotein homolog
NHP2-like protein
nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
snoRNP protein NHP2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011765.1 RefSeqGene

    Range
    5001..9498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_346

mRNA and Protein(s)

  1. NM_001034833.1NP_001030005.1  H/ACA ribonucleoprotein complex subunit 2 isoform b

    See identical proteins and their annotated locations for NP_001030005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AJ293309, BG827491, BM913344
    Consensus CDS
    CCDS34308.1
    UniProtKB/Swiss-Prot
    Q9NX24
    UniProtKB/TrEMBL
    J3QSY4
    Related
    ENSP00000366276.2, ENST00000314397.8
    Conserved Domains (1) summary
    cl00600
    Location:4677
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  2. NM_017838.4NP_060308.1  H/ACA ribonucleoprotein complex subunit 2 isoform a

    See identical proteins and their annotated locations for NP_060308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AJ293309, BC000009, BE797477
    Consensus CDS
    CCDS4432.1
    UniProtKB/Swiss-Prot
    Q9NX24
    Related
    ENSP00000274606.3, ENST00000274606.7
    Conserved Domains (1) summary
    pfam01248
    Location:46139
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    178149463..178153960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center