Format

Send to:

Choose Destination

FLVCR2 FLVCR heme transporter 2 [ Homo sapiens (human) ]

Gene ID: 55640, updated on 4-Jun-2020

Summary

Official Symbol
FLVCR2provided by HGNC
Official Full Name
FLVCR heme transporter 2provided by HGNC
Primary source
HGNC:HGNC:20105
See related
Ensembl:ENSG00000119686 MIM:610865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCT; EPV; PVHH; MFSD7C; SLC49A2; C14orf58; FLVCRL14q
Summary
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Expression
Broad expression in small intestine (RPKM 10.8), testis (RPKM 9.1) and 21 other tissues See more
Orthologs

Genomic context

See FLVCR2 in Genome Data Viewer
Location:
14q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75578620..75648167)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (76044940..76114512)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC107984652 Neighboring gene uncharacterized LOC107984653 Neighboring gene uncharacterized LOC102724153 Neighboring gene ribosomal protein S24 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 387 Neighboring gene Sharpr-MPRA regulatory region 2473 Neighboring gene ergosterol biosynthesis 28 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TTLL5

Homology

Clone Names

  • FLJ20371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
heme transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
heme export IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
feline leukemia virus subgroup C receptor-related protein 2
Names
calcium-chelate transporter
feline leukemia virus subgroup C cellular receptor family member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027694.1 RefSeqGene

    Range
    5024..74571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195283.2NP_001182212.1  feline leukemia virus subgroup C receptor-related protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001182212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297002, AY260577, CR739521
    Consensus CDS
    CCDS55933.1
    UniProtKB/Swiss-Prot
    Q9UPI3
    Related
    ENSP00000443439.1, ENST00000539311.5
    Conserved Domains (2) summary
    cd06174
    Location:19283
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:19249
    MFS_1; Major Facilitator Superfamily
  2. NM_017791.3NP_060261.2  feline leukemia virus subgroup C receptor-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060261.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY260577, BC019087, CR739521, DA166212
    Consensus CDS
    CCDS9844.1
    UniProtKB/Swiss-Prot
    Q9UPI3
    Related
    ENSP00000238667.4, ENST00000238667.9
    Conserved Domains (1) summary
    cd06174
    Location:88488
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75578620..75648167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center