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PNRC2 proline rich nuclear receptor coactivator 2 [ Homo sapiens (human) ]

Gene ID: 55629, updated on 5-Aug-2022

Summary

Official Symbol
PNRC2provided by HGNC
Official Full Name
proline rich nuclear receptor coactivator 2provided by HGNC
Primary source
HGNC:HGNC:23158
See related
Ensembl:ENSG00000189266 MIM:611882; AllianceGenome:HGNC:23158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: GeneID 100132235 was merged into this record because the clone on which it was annotated, BX511012.5, was determined to be redundent. [27 May 2009]
Expression
Ubiquitous expression in thyroid (RPKM 68.8), lymph node (RPKM 67.1) and 25 other tissues See more
Orthologs
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Genomic context

See PNRC2 in Genome Data Viewer
Location:
1p36.11
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23959164..23963462)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23797250..23800884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24286318..24289952)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 378f Neighboring gene uncharacterized LOC124903877 Neighboring gene H3 histone pseudogene 1 Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene uncharacterized LOC105378615

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20312, MGC99541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proline-rich nuclear receptor coactivator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017761.4NP_060231.1  proline-rich nuclear receptor coactivator 2

    See identical proteins and their annotated locations for NP_060231.1

    Status: VALIDATED

    Source sequence(s)
    AK311305, BC001959, BC078177, DA043474
    Consensus CDS
    CCDS246.1
    UniProtKB/Swiss-Prot
    B4DU72, Q9NPJ4
    UniProtKB/TrEMBL
    A0A024RAC2
    Related
    ENSP00000334840.7, ENST00000334351.8
    Conserved Domains (1) summary
    pfam15365
    Location:91137
    PNRC; Proline-rich nuclear receptor coactivator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23959164..23963462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001691.1XP_016857180.1  proline-rich nuclear receptor coactivator 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DU72, Q9NPJ4
    UniProtKB/TrEMBL
    A0A024RAC2
    Related
    ENSP00000497590.1, ENST00000647887.1
    Conserved Domains (1) summary
    pfam15365
    Location:91137
    PNRC; Proline-rich nuclear receptor coactivator

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23797250..23800884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)