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PNRC2 proline rich nuclear receptor coactivator 2 [ Homo sapiens (human) ]

Gene ID: 55629, updated on 8-Oct-2018

Summary

Official Symbol
PNRC2provided by HGNC
Official Full Name
proline rich nuclear receptor coactivator 2provided by HGNC
Primary source
HGNC:HGNC:23158
See related
Ensembl:ENSG00000189266 MIM:611882; Vega:OTTHUMG00000013891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
Note: GeneID 100132235 was merged into this record because the clone on which it was annotated, BX511012.5, was determined to be redundent. [27 May 2009]
Expression
Ubiquitous expression in thyroid (RPKM 68.8), lymph node (RPKM 67.1) and 25 other tissues See more
Orthologs

Genomic context

See PNRC2 in Genome Data Viewer
Location:
1p36.11
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (23959164..23963462)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24286301..24289952)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor 2 Neighboring gene uncharacterized LOC107984929 Neighboring gene microRNA 378f Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene uncharacterized LOC105378615

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20312, MGC99541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proline-rich nuclear receptor coactivator 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017761.3NP_060231.1  proline-rich nuclear receptor coactivator 2

    See identical proteins and their annotated locations for NP_060231.1

    Status: VALIDATED

    Source sequence(s)
    AK311305, BC001959, BC078177, DA043474
    Consensus CDS
    CCDS246.1
    UniProtKB/Swiss-Prot
    Q9NPJ4
    UniProtKB/TrEMBL
    A0A024RAC2
    Related
    ENSP00000334840.7, OTTHUMP00000015770, ENST00000334351.7, OTTHUMT00000038946
    Conserved Domains (1) summary
    pfam15365
    Location:91137
    PNRC; Proline-rich nuclear receptor coactivator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    23959164..23963462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001691.1XP_016857180.1  proline-rich nuclear receptor coactivator 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NPJ4
    UniProtKB/TrEMBL
    A0A024RAC2
    Related
    ENSP00000497590.1, ENST00000647887.1
    Conserved Domains (1) summary
    pfam15365
    Location:91137
    PNRC; Proline-rich nuclear receptor coactivator
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