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ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 55625, updated on 24-Nov-2020

Summary

Official Symbol
ZDHHC7provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:18459
See related
Ensembl:ENSG00000153786 MIM:614604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC7; SERZ1; SERZ-B; ZNF370
Expression
Ubiquitous expression in bone marrow (RPKM 20.6), lung (RPKM 20.0) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC7 in Genome Data Viewer
Location:
16q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (84974175..85011535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85008066..85045141, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928474 Neighboring gene interferon induced transmembrane protein pseudogene Neighboring gene long intergenic non-protein coding RNA 2176 Neighboring gene KIAA0513 Neighboring gene uncharacterized LOC105371380 Neighboring gene CBY1 interacting BAR domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10792, FLJ20279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarized epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Fas signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC7
Names
DHHC-7
Sertoli cell gene with zinc finger domain-I(2)
Sertoli cell gene with zinc finger domain-beta
acyltransferase ZDHHC7
zinc finger DHHC domain-containing protein 7
zinc finger DHHC-type containing 7
zinc finger protein 370
zinc finger, DHHC domain containing 7
NP_001139020.1
NP_060210.2
XP_011521524.1
XP_024306111.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145548.2NP_001139020.1  palmitoyltransferase ZDHHC7 isoform 1

    See identical proteins and their annotated locations for NP_001139020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092341, AW235073, BC018772, DA507340
    Consensus CDS
    CCDS45538.1
    UniProtKB/Swiss-Prot
    Q9NXF8
    Related
    ENSP00000456782.1, ENST00000564466.5
    Conserved Domains (1) summary
    pfam01529
    Location:168295
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_017740.3NP_060210.2  palmitoyltransferase ZDHHC7 isoform 2

    See identical proteins and their annotated locations for NP_060210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon but maintains the reading frame compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC092341, AK000286, AW235073, CN427219, DA507340
    Consensus CDS
    CCDS10950.1
    UniProtKB/Swiss-Prot
    Q9NXF8
    Related
    ENSP00000315604.4, ENST00000313732.8
    Conserved Domains (1) summary
    pfam01529
    Location:131258
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    84974175..85011535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450343.1XP_024306111.1  palmitoyltransferase ZDHHC7 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:131258
    DHHC; DHHC palmitoyltransferase
  2. XM_011523222.2XP_011521524.1  palmitoyltransferase ZDHHC7 isoform X2

RNA

  1. XR_429724.4 RNA Sequence

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