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Zdhhc7 zinc finger, DHHC domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 102193, updated on 18-Apr-2024

Summary

Official Symbol
Zdhhc7provided by MGI
Official Full Name
zinc finger, DHHC domain containing 7provided by MGI
Primary source
MGI:MGI:2142662
See related
Ensembl:ENSMUSG00000031823 AllianceGenome:MGI:2142662
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gramp2
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in glucose import in response to insulin stimulus; peptidyl-L-cysteine S-palmitoylation; and regulation of protein localization to plasma membrane. Located in Golgi apparatus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZDHHC7 (zinc finger DHHC-type palmitoyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 81.1), adrenal adult (RPKM 55.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 E1; 8 68.93 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120807834..120828211, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120081091..120103900, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:122434591-122434892 Neighboring gene ubiquitin specific peptidase 10 Neighboring gene STARR-seq mESC enhancer starr_22870 Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122556487-122556718 Neighboring gene RIKEN cDNA A130014A01 gene Neighboring gene RIKEN cDNA 6430548M08 gene Neighboring gene STARR-positive B cell enhancer ABC_E3811

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import in response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in polarized epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of Fas signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC7
Names
DHHC-7
GABA-A receptor-associated membrane protein 2
SERZ-beta
acyltransferase ZDHHC7
zinc finger DHHC domain-containing protein 7
NP_598728.1
XP_011246559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133967.3NP_598728.1  palmitoyltransferase ZDHHC7

    See identical proteins and their annotated locations for NP_598728.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075666
    Consensus CDS
    CCDS22715.1
    UniProtKB/Swiss-Prot
    Q3TC41, Q6EMK2, Q8K1H6, Q91WU6
    Related
    ENSMUSP00000034280.8, ENSMUST00000034280.9
    Conserved Domains (1) summary
    pfam01529
    Location:131258
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120807834..120828211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248257.4XP_011246559.1  palmitoyltransferase ZDHHC7 isoform X1

    See identical proteins and their annotated locations for XP_011246559.1

    UniProtKB/Swiss-Prot
    Q3TC41, Q6EMK2, Q8K1H6, Q91WU6
    Conserved Domains (1) summary
    pfam01529
    Location:131258
    DHHC; DHHC palmitoyltransferase