Format

Send to:

Choose Destination

KIF16B kinesin family member 16B [ Homo sapiens (human) ]

Gene ID: 55614, updated on 17-Jun-2019

Summary

Official Symbol
KIF16Bprovided by HGNC
Official Full Name
kinesin family member 16Bprovided by HGNC
Primary source
HGNC:HGNC:15869
See related
Ensembl:ENSG00000089177 MIM:618171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX23; C20orf23; KISC20ORF
Summary
The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in adrenal (RPKM 10.5), colon (RPKM 7.0) and 24 other tissues See more
Orthologs

Genomic context

See KIF16B in Genome Data Viewer
Location:
20p12.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (16272104..16573457, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (16252742..16554079, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene uncharacterized LOC613266 Neighboring gene peptidylprolyl isomerase A pseudogene 17 Neighboring gene uncharacterized LOC105372541 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.
NHGRI GWA Catalog
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
NHGRI GWA Catalog

Pathways from BioSystems

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-dependent microtubule motor activity, plus-end-directed IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
formation of primary germ layer ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF16B
Names
kinesin motor protein
sorting nexin 23
testis secretory sperm-binding protein Li 201a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028043.2 RefSeqGene

    Range
    5001..306331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199865.2NP_001186794.1  kinesin-like protein KIF16B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577
    Consensus CDS
    CCDS82598.1
    UniProtKB/Swiss-Prot
    Q96L93
    UniProtKB/TrEMBL
    A0A1B0GTU3
    Related
    ENSP00000489838.1, ENST00000636835.1
    Conserved Domains (8) summary
    cd06874
    Location:11331260
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:5971087
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607807
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001199866.2NP_001186795.1  kinesin-like protein KIF16B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577, BC150261
    Consensus CDS
    CCDS56178.1
    UniProtKB/Swiss-Prot
    Q96L93
    Related
    ENSP00000384164.1, ENST00000408042.5
    Conserved Domains (6) summary
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam09755
    Location:608881
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    pfam13476
    Location:615776
    AAA_23; AAA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
  3. NM_024704.5NP_078980.3  kinesin-like protein KIF16B isoform 2

    See identical proteins and their annotated locations for NP_078980.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577
    Consensus CDS
    CCDS13122.1
    UniProtKB/Swiss-Prot
    Q96L93
    UniProtKB/TrEMBL
    A0A140VK74
    Related
    ENSP00000347076.2, ENST00000354981.6
    Conserved Domains (8) summary
    cd06874
    Location:11841311
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:5971081
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607807
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    16272104..16573457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260755.3XP_005260812.1  kinesin-like protein KIF16B isoform X7

    Conserved Domains (8) summary
    cd06874
    Location:11441271
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:6081098
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_017027926.1XP_016883415.1  kinesin-like protein KIF16B isoform X8

    UniProtKB/Swiss-Prot
    Q96L93
  3. XM_006723588.3XP_006723651.1  kinesin-like protein KIF16B isoform X6

    Conserved Domains (8) summary
    cd06874
    Location:11781281
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:6081092
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. XM_005260754.3XP_005260811.1  kinesin-like protein KIF16B isoform X5

    Conserved Domains (8) summary
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:6081092
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl02563
    Location:11951292
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. XM_005260753.3XP_005260810.1  kinesin-like protein KIF16B isoform X4

    Conserved Domains (8) summary
    cd06874
    Location:11951322
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam09755
    Location:619892
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. XM_005260751.4XP_005260808.1  kinesin-like protein KIF16B isoform X2

    Conserved Domains (7) summary
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam13868
    Location:599923
    TPH; Trichohyalin-plectin-homology domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607807
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. XM_005260752.3XP_005260809.1  kinesin-like protein KIF16B isoform X3

    Conserved Domains (8) summary
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG4372
    Location:8201093
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam13868
    Location:610934
    TPH; Trichohyalin-plectin-homology domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. XM_005260750.3XP_005260807.1  kinesin-like protein KIF16B isoform X1

    Conserved Domains (7) summary
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam13868
    Location:610934
    TPH; Trichohyalin-plectin-homology domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618818
    GBP_C; Guanylate-binding protein, C-terminal domain
  9. XM_024451936.1XP_024307704.1  kinesin-like protein KIF16B isoform X9

    Conserved Domains (1) summary
    cl25732
    Location:2463
    SMC_N; RecF/RecN/SMC N terminal domain
Support Center