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Kif16b kinesin family member 16B [ Mus musculus (house mouse) ]

Gene ID: 16558, updated on 18-Apr-2024

Summary

Official Symbol
Kif16bprovided by MGI
Official Full Name
kinesin family member 16Bprovided by MGI
Primary source
MGI:MGI:1098240
See related
Ensembl:ENSMUSG00000038844 AllianceGenome:MGI:1098240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1590; 8430434E15Rik
Summary
Enables small GTPase binding activity. Involved in several processes, including Golgi to endosome transport; endoderm development; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within cellular response to interferon-gamma. Located in phagocytic vesicle. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 2.8), kidney adult (RPKM 2.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 G1; 2 70.67 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (142459399..142743535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (142618340..142901609, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26, pseudogene 5 Neighboring gene RNA binding motif protein, X-linked 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05874 Neighboring gene STARR-seq mESC enhancer starr_05875 Neighboring gene STARR-seq mESC enhancer starr_05876 Neighboring gene STARR-positive B cell enhancer mm9_chr2:142638896-142639197 Neighboring gene predicted gene, 22310 Neighboring gene STARR-positive B cell enhancer ABC_E5991 Neighboring gene STARR-positive B cell enhancer ABC_E4505 Neighboring gene STARR-positive B cell enhancer ABC_E2049 Neighboring gene kinesin family member 16B, opposite strand Neighboring gene STARR-seq mESC enhancer starr_05877 Neighboring gene STARR-positive B cell enhancer ABC_E3408 Neighboring gene U2 small nuclear ribonucleoprotein B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables plus-end-directed microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF16B
Names
N-3 kinesin
kinesin 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081133.3NP_001074602.1  kinesin-like protein KIF16B isoform 2

    See identical proteins and their annotated locations for NP_001074602.1

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL731790, AL929136
    Consensus CDS
    CCDS38251.1
    UniProtKB/Swiss-Prot
    B1AVY7, O35056, Q3TUD2, Q6ZPM0, Q8BZZ9
    UniProtKB/TrEMBL
    A0A1D5RMD4
    Related
    ENSMUSP00000042551.8, ENSMUST00000043589.8
    Conserved Domains (6) summary
    cd06874
    Location:11791306
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cl23765
    Location:602724
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_001355123.2NP_001342052.1  kinesin-like protein KIF16B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL731790, AL929136
    Consensus CDS
    CCDS89559.1
    UniProtKB/TrEMBL
    A0A1D5RMD4, E7FLY0
    Related
    ENSMUSP00000154926.2, ENSMUST00000230763.2
    Conserved Domains (5) summary
    cd06874
    Location:11901317
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
    cl25732
    Location:613867
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001421415.1NP_001408344.1  kinesin-like protein KIF16B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL929136
  4. NM_001421416.1NP_001408345.1  kinesin-like protein KIF16B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL929136
  5. NM_001421417.1NP_001408346.1  kinesin-like protein KIF16B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL731790, AL929136
  6. NM_001421418.1NP_001408347.1  kinesin-like protein KIF16B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL731790, AL929136
  7. NM_001421419.1NP_001408348.1  kinesin-like protein KIF16B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL731712, AL731790, AL929136

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    142459399..142743535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158820.1XP_036014713.1  kinesin-like protein KIF16B isoform X10

    UniProtKB/TrEMBL
    A0A1D5RMD4
    Conserved Domains (6) summary
    cd06874
    Location:11621265
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    COG1196
    Location:602856
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:7591073
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:2365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478543
    FHA; FHA domain
    pfam16183
    Location:364476
    Kinesin_assoc; Kinesin-associated
  2. XM_036158819.1XP_036014712.1  kinesin-like protein KIF16B isoform X9

    Conserved Domains (6) summary
    cd06874
    Location:11621289
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    COG0419
    Location:6311163
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:636890
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01365
    Location:51399
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:512577
    FHA; FHA domain
    pfam16183
    Location:398510
    Kinesin_assoc; Kinesin-associated
  3. XM_036158817.1XP_036014710.1  kinesin-like protein KIF16B isoform X8

    UniProtKB/TrEMBL
    A0A1D5RMD4
    Conserved Domains (5) summary
    cd06874
    Location:12071310
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    COG0419
    Location:6441081
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:51399
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:512577
    FHA; FHA domain
    pfam16183
    Location:398510
    Kinesin_assoc; Kinesin-associated
  4. XM_036158812.1XP_036014705.1  kinesin-like protein KIF16B isoform X5

    Conserved Domains (4) summary
    COG0419
    Location:6421145
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:51399
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:512577
    FHA; FHA domain
    pfam16183
    Location:398510
    Kinesin_assoc; Kinesin-associated
  5. XM_036158800.1XP_036014693.1  kinesin-like protein KIF16B isoform X1

    Conserved Domains (4) summary
    COG0419
    Location:6441081
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:51399
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:512577
    FHA; FHA domain
    pfam16183
    Location:398510
    Kinesin_assoc; Kinesin-associated
  6. XM_036158804.1XP_036014697.1  kinesin-like protein KIF16B isoform X2

    Conserved Domains (4) summary
    COG0419
    Location:6331070
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:51399
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:512577
    FHA; FHA domain
    pfam16183
    Location:398510
    Kinesin_assoc; Kinesin-associated