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VEZT vezatin, adherens junctions transmembrane protein [ Homo sapiens (human) ]

Gene ID: 55591, updated on 5-Jan-2022

Summary

Official Symbol
VEZTprovided by HGNC
Official Full Name
vezatin, adherens junctions transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:18258
See related
Ensembl:ENSG00000028203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VEZATIN
Summary
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in thyroid (RPKM 16.2), placenta (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See VEZT in Genome Data Viewer
Location:
12q22
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (95217746..95302799)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95611583..95696575)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268099 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene ribosomal protein L14 pseudogene 4 Neighboring gene RNA, U6 small nuclear 808, pseudogene Neighboring gene chromobox 3 pseudogene 5 Neighboring gene microRNA 3685 Neighboring gene microRNA 331

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association meta-analysis identifies new endometriosis risk loci.
EBI GWAS Catalog
Genome-wide association study link novel loci to endometriosis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761C241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables myosin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of stereocilia ankle link complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in stereocilium membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028987.2 RefSeqGene

    Range
    5062..90054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001352088.2NP_001339017.1  vezatin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (a).
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:169461
    Vezatin; Mysoin-binding motif of peroxisomes
  2. NM_001352089.2NP_001339018.1  vezatin isoform c

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150442
    Vezatin; Mysoin-binding motif of peroxisomes
  3. NM_001352090.2NP_001339019.1  vezatin isoform d

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:120408
    Vezatin; Mysoin-binding motif of peroxisomes
  4. NM_001352091.2NP_001339020.1  vezatin isoform e

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:119407
    Vezatin; Mysoin-binding motif of peroxisomes
  5. NM_001352092.2NP_001339021.1  vezatin isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform f.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  6. NM_001352093.2NP_001339022.1  vezatin isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform f.
    Source sequence(s)
    AC084879, AC127165
    Related
    ENSP00000380894.4, ENST00000397792.8
    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  7. NM_001352094.2NP_001339023.1  vezatin isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform g.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:102390
    Vezatin; Mysoin-binding motif of peroxisomes
  8. NM_001352095.2NP_001339024.1  vezatin isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform g.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:102390
    Vezatin; Mysoin-binding motif of peroxisomes
  9. NM_001352096.2NP_001339025.1  vezatin isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform g.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:102390
    Vezatin; Mysoin-binding motif of peroxisomes
  10. NM_001352097.2NP_001339026.1  vezatin isoform h

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:72364
    Vezatin; Mysoin-binding motif of peroxisomes
  11. NM_001352098.2NP_001339027.1  vezatin isoform i

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150359
    Vezatin; Mysoin-binding motif of peroxisomes
  12. NM_001352099.2NP_001339028.1  vezatin isoform j

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:12304
    Vezatin; Mysoin-binding motif of peroxisomes
  13. NM_001352100.2NP_001339029.1  vezatin isoform k

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:169457
    Vezatin; Mysoin-binding motif of peroxisomes
  14. NM_001352101.2NP_001339030.1  vezatin isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform l.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  15. NM_001352102.2NP_001339031.1  vezatin isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform l.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  16. NM_001352103.2NP_001339032.1  vezatin isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 20, 21, 22, and 23, encodes isoform m.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  17. NM_001352104.2NP_001339033.1  vezatin isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 19, 21, 22, and 23, encodes isoform m.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  18. NM_001352105.2NP_001339034.1  vezatin isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 19, 20, 22, and 23, encodes isoform m.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  19. NM_001352106.2NP_001339035.1  vezatin isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 19, 20, 21, and 23, encodes isoform m.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  20. NM_001352107.2NP_001339036.1  vezatin isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 19, 20, 21, and 22, encodes isoform m.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  21. NM_001352108.2NP_001339037.1  vezatin isoform n

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150442
    Vezatin; Mysoin-binding motif of peroxisomes
  22. NM_001352109.2NP_001339038.1  vezatin isoform o

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150442
    Vezatin; Mysoin-binding motif of peroxisomes
  23. NM_001352110.2NP_001339039.1  vezatin isoform v

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150438
    Vezatin; Mysoin-binding motif of peroxisomes
  24. NM_001352111.2NP_001339040.1  vezatin isoform p

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:150438
    Vezatin; Mysoin-binding motif of peroxisomes
  25. NM_001352112.2NP_001339041.1  vezatin isoform q

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:119407
    Vezatin; Mysoin-binding motif of peroxisomes
  26. NM_001352113.2NP_001339042.1  vezatin isoform r

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:102390
    Vezatin; Mysoin-binding motif of peroxisomes
  27. NM_001352114.2NP_001339043.1  vezatin isoform s

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2207
    Vezatin; Mysoin-binding motif of peroxisomes
  28. NM_001352115.2NP_001339044.1  vezatin isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 32 and 33, encodes isoform t.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  29. NM_001352116.2NP_001339045.1  vezatin isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 31 and 33, encodes isoform t.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  30. NM_001352117.2NP_001339046.1  vezatin isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 31 and 32, encodes isoform t.
    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  31. NM_001352118.2NP_001339047.1  vezatin isoform w

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  32. NM_001352119.2NP_001339048.1  vezatin isoform u

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
    Conserved Domains (1) summary
    pfam12632
    Location:2290
    Vezatin; Mysoin-binding motif of peroxisomes
  33. NM_017599.4NP_060069.3  vezatin isoform b

    See identical proteins and their annotated locations for NP_060069.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform b.
    Source sequence(s)
    AC084879, AF225417, AK225303, AL133113, BI835735, BQ023048, DB136255
    Consensus CDS
    CCDS44954.1
    UniProtKB/Swiss-Prot
    Q9HBM0
    Related
    ENSP00000410083.1, ENST00000436874.6
    Conserved Domains (1) summary
    pfam12632
    Location:150438
    Vezatin; Mysoin-binding motif of peroxisomes

RNA

  1. NR_038241.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC084879, AC127165, AK225303, BQ023048
  2. NR_038242.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC084879, AC127165, BC014443, BQ023048
  3. NR_147917.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  4. NR_147918.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  5. NR_147919.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  6. NR_147920.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  7. NR_147921.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  8. NR_147922.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  9. NR_147923.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  10. NR_147924.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  11. NR_147925.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165
  12. NR_147926.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC084879, AC127165

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    95217746..95302799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019593.1XP_016875082.1  vezatin isoform X13

    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  2. XM_011538545.2XP_011536847.1  vezatin isoform X2

    Conserved Domains (1) summary
    pfam12632
    Location:139431
    Vezatin; Mysoin-binding motif of peroxisomes
  3. XM_017019599.2XP_016875088.1  vezatin isoform X14

  4. XM_017019586.1XP_016875075.1  vezatin isoform X3

  5. XM_006719478.2XP_006719541.1  vezatin isoform X4

    Conserved Domains (1) summary
    pfam12632
    Location:120412
    Vezatin; Mysoin-binding motif of peroxisomes
  6. XM_011538548.3XP_011536850.1  vezatin isoform X8

    Conserved Domains (1) summary
    pfam12632
    Location:57349
    Vezatin; Mysoin-binding motif of peroxisomes
  7. XM_017019592.2XP_016875081.1  vezatin isoform X9

  8. XM_024449040.1XP_024304808.1  vezatin isoform X5

    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  9. XM_011538549.1XP_011536851.1  vezatin isoform X10

    Conserved Domains (1) summary
    pfam12632
    Location:169461
    Vezatin; Mysoin-binding motif of peroxisomes
  10. XM_024449042.1XP_024304810.1  vezatin isoform X12

    Conserved Domains (1) summary
    pfam12632
    Location:169457
    Vezatin; Mysoin-binding motif of peroxisomes
  11. XM_011538544.1XP_011536846.1  vezatin isoform X1

    Conserved Domains (1) summary
    pfam12632
    Location:169457
    Vezatin; Mysoin-binding motif of peroxisomes
  12. XM_011538550.3XP_011536852.1  vezatin isoform X11

    See identical proteins and their annotated locations for XP_011536852.1

    Conserved Domains (1) summary
    pfam12632
    Location:169461
    Vezatin; Mysoin-binding motif of peroxisomes
  13. XM_017019594.1XP_016875083.1  vezatin isoform X13

    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  14. XM_011538546.1XP_011536848.1  vezatin isoform X5

    See identical proteins and their annotated locations for XP_011536848.1

    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  15. XM_017019602.1XP_016875091.1  vezatin isoform X15

    UniProtKB/Swiss-Prot
    Q9HBM0
    Conserved Domains (1) summary
    pfam12632
    Location:102390
    Vezatin; Mysoin-binding motif of peroxisomes
  16. XM_011538547.1XP_011536849.1  vezatin isoform X5

    See identical proteins and their annotated locations for XP_011536849.1

    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  17. XM_024449041.1XP_024304809.1  vezatin isoform X5

    Conserved Domains (1) summary
    pfam12632
    Location:102394
    Vezatin; Mysoin-binding motif of peroxisomes
  18. XM_006719482.3XP_006719545.1  vezatin isoform X6

    See identical proteins and their annotated locations for XP_006719545.1

    Conserved Domains (1) summary
    pfam12632
    Location:72364
    Vezatin; Mysoin-binding motif of peroxisomes
  19. XM_017019591.1XP_016875080.1  vezatin isoform X7

  20. XM_006719483.4XP_006719546.1  vezatin isoform X13

    See identical proteins and their annotated locations for XP_006719546.1

    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  21. XM_006719484.3XP_006719547.1  vezatin isoform X13

    See identical proteins and their annotated locations for XP_006719547.1

    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes
  22. XM_024449043.1XP_024304811.1  vezatin isoform X13

    Conserved Domains (1) summary
    pfam12632
    Location:2294
    Vezatin; Mysoin-binding motif of peroxisomes

RNA

  1. XR_001748801.2 RNA Sequence

  2. XR_001748800.2 RNA Sequence

  3. XR_001748799.2 RNA Sequence

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