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CNOT11 CCR4-NOT transcription complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 55571, updated on 3-May-2025
Official Symbol
CNOT11provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:25217
See related
Ensembl:ENSG00000158435 MIM:620509; AllianceGenome:HGNC:25217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C40; C2orf29
Summary
Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in testis (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more
Orthologs
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See CNOT11 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101252886..101270316)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101711589..101729019)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101869348..101886778)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101768548-101769048 Neighboring gene TBC1D8 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101775410-101776609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:101779352-101779869 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101866397-101866896 Neighboring gene uncharacterized LOC124906053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165 Neighboring gene uncharacterized LOC105373511 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
 
part_of CCR4-NOT complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
CCR4-NOT transcription complex subunit 11
Names
UPF0760 protein C2orf29

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017546.5NP_060016.3  CCR4-NOT transcription complex subunit 11

    See identical proteins and their annotated locations for NP_060016.3

    Status: VALIDATED

    Source sequence(s)
    BC018664, BM923954, BX394182
    Consensus CDS
    CCDS2050.1
    UniProtKB/Swiss-Prot
    Q6P2M9, Q8N681, Q9UKZ1
    Related
    ENSP00000289382.3, ENST00000289382.8
    Conserved Domains (1) summary
    pfam10155
    Location:371494
    DUF2363; Uncharacterized conserved protein (DUF2363)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101252886..101270316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101711589..101729019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)