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CNOT11 CCR4-NOT transcription complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 55571, updated on 4-Dec-2022

Summary

Official Symbol
CNOT11provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:25217
See related
Ensembl:ENSG00000158435 AllianceGenome:HGNC:25217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C40; C2orf29
Summary
Predicted to be involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more
Orthologs
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Genomic context

See CNOT11 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101252886..101270316)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101711589..101729019)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101869348..101886778)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene TBC1D8 antisense RNA 1 Neighboring gene uncharacterized LOC124906053 Neighboring gene uncharacterized LOC105373511 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CCR4-NOT complex IC
Inferred by Curator
more info
PubMed 
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 11
Names
UPF0760 protein C2orf29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017546.5NP_060016.3  CCR4-NOT transcription complex subunit 11

    See identical proteins and their annotated locations for NP_060016.3

    Status: VALIDATED

    Source sequence(s)
    BC018664, BM923954, BX394182
    Consensus CDS
    CCDS2050.1
    UniProtKB/Swiss-Prot
    Q8N681, Q9UKZ1
    Related
    ENSP00000289382.3, ENST00000289382.8
    Conserved Domains (1) summary
    pfam10155
    Location:371494
    DUF2363; Uncharacterized conserved protein (DUF2363)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101252886..101270316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101711589..101729019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)