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KLK15 kallikrein related peptidase 15 [ Homo sapiens (human) ]

Gene ID: 55554, updated on 8-Jul-2021

Summary

Official Symbol
KLK15provided by HGNC
Official Full Name
kallikrein related peptidase 15provided by HGNC
Primary source
HGNC:HGNC:20453
See related
Ensembl:ENSG00000174562 MIM:610601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACO; HSRNASPH
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues See more
Orthologs
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Genomic context

See KLK15 in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (50825289..50834337, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51328545..51334779, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1869 Neighboring gene kallikrein 1 Neighboring gene uncharacterized LOC105372441 Neighboring gene KLK3 upstream enhancer/promoter region Neighboring gene kallikrein related peptidase 3 Neighboring gene KLK2 upstream enhancer/promoter region Neighboring gene origin of replication 20mer2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
GeneReviews: Not available
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-15
Names
ACO protease
kallikrein-like serine protease
prostinogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029894.1 RefSeqGene

    Range
    5001..11235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001277081.2NP_001264010.1  kallikrein-15 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_001264010.1

    Status: REVIEWED

    Source sequence(s)
    AC010325
    Consensus CDS
    CCDS62766.1
    UniProtKB/Swiss-Prot
    Q9H2R5
    UniProtKB/TrEMBL
    Q6UBM2
    Related
    ENSP00000314783.4, ENST00000326856.8
    Conserved Domains (2) summary
    smart00020
    Location:24248
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24251
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001277082.2NP_001264011.1  kallikrein-15 isoform 6 preproprotein

    See identical proteins and their annotated locations for NP_001264011.1

    Status: REVIEWED

    Source sequence(s)
    AC010325
    Consensus CDS
    CCDS12806.2
    UniProtKB/Swiss-Prot
    Q9H2R5
    UniProtKB/TrEMBL
    M0R0D7, Q6UBM2
    Related
    ENSP00000471164.1, ENST00000596931.5
    Conserved Domains (2) summary
    smart00020
    Location:24150
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24150
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_017509.4NP_059979.2  kallikrein-15 isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_059979.2

    Status: REVIEWED

    Source sequence(s)
    AC010325
    Consensus CDS
    CCDS12805.1
    UniProtKB/Swiss-Prot
    Q9H2R5
    UniProtKB/TrEMBL
    Q6UBM2
    Related
    ENSP00000469315.1, ENST00000598239.5
    Conserved Domains (1) summary
    smart00020
    Location:25249
    Tryp_SPc; Trypsin-like serine protease

RNA

  1. NR_102274.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in two internal exons, compared to variant 4. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW205420, AY373373, BC069518, BC144045

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    50825289..50834337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527089.2XP_011525391.1  kallikrein-15 isoform X5

    UniProtKB/TrEMBL
    M0R0D7
    Conserved Domains (2) summary
    smart00020
    Location:24150
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24150
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011527087.2XP_011525389.1  kallikrein-15 isoform X3

    See identical proteins and their annotated locations for XP_011525389.1

    UniProtKB/Swiss-Prot
    Q9H2R5
    Conserved Domains (1) summary
    cd00190
    Location:25167
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006723265.3XP_006723328.1  kallikrein-15 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2R5
    Conserved Domains (1) summary
    smart00020
    Location:25249
    Tryp_SPc; Trypsin-like serine protease
  4. XM_011527085.2XP_011525387.1  kallikrein-15 isoform X2

    UniProtKB/Swiss-Prot
    Q9H2R5
    Conserved Domains (2) summary
    smart00020
    Location:24248
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24251
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_011527088.2XP_011525390.1  kallikrein-15 isoform X4

    See identical proteins and their annotated locations for XP_011525390.1

    UniProtKB/Swiss-Prot
    Q9H2R5
    Conserved Domains (2) summary
    smart00020
    Location:25151
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25151
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_017026943.1XP_016882432.1  kallikrein-15 isoform X6

    UniProtKB/Swiss-Prot
    Q9H2R5
    Related
    ENSP00000468856.1, ENST00000602114.1
    Conserved Domains (2) summary
    smart00020
    Location:25120
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25120
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_001753713.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023006.1: Suppressed sequence

    Description
    NM_023006.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_138563.1: Suppressed sequence

    Description
    NM_138563.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.
  3. NM_138564.1: Suppressed sequence

    Description
    NM_138564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.
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