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TRPV6 transient receptor potential cation channel subfamily V member 6 [ Homo sapiens (human) ]

Gene ID: 55503, updated on 3-May-2020

Summary

Official Symbol
TRPV6provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 6provided by HGNC
Primary source
HGNC:HGNC:14006
See related
Ensembl:ENSG00000165125 MIM:606680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT1; CATL; ZFAB; ECAC2; ABP/ZF; HRPTTN; LP6728; HSA277909
Summary
This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]
Expression
Biased expression in prostate (RPKM 26.0), salivary gland (RPKM 21.3) and 9 other tissues See more
Orthologs

Genomic context

See TRPV6 in Genome Data Viewer
Location:
7q34
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142871208..142885745, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142568956..142583490, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.5168 Neighboring gene EPH receptor B6 Neighboring gene transient receptor potential cation channel subfamily V member 5 Neighboring gene uncharacterized LOC105375542

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
regulation of calcium ion-dependent exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 6
Names
Alu-binding protein with zinc finger domain
calcium transport protein 1
calcium transporter-like protein
epithelial apical membrane calcium transporter/channel CaT1
epithelial calcium channel 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050669.1 RefSeqGene

    Range
    5001..19543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018646.6NP_061116.5  transient receptor potential cation channel subfamily V member 6

    See identical proteins and their annotated locations for NP_061116.5

    Status: REVIEWED

    Source sequence(s)
    AC245427
    Consensus CDS
    CCDS5874.2
    UniProtKB/Swiss-Prot
    Q9H1D0
    Related
    ENSP00000352358.4, ENST00000359396.8
    Conserved Domains (3) summary
    cd00204
    Location:119242
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52698
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:156187
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142871208..142885745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    894250..908785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014274.3: Suppressed sequence

    Description
    NM_014274.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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