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HEMGN hemogen [ Homo sapiens (human) ]

Gene ID: 55363, updated on 7-Jun-2020

Summary

Official Symbol
HEMGNprovided by HGNC
Official Full Name
hemogenprovided by HGNC
Primary source
HGNC:HGNC:17509
See related
Ensembl:ENSG00000136929 MIM:610715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR; EDAG; CT155; EDAG-1
Expression
Biased expression in bone marrow (RPKM 77.2) and testis (RPKM 23.8) See more
Orthologs

Genomic context

See HEMGN in Genome Data Viewer
Location:
9q22.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (97926791..97944852, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100689073..100707197, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268051 Neighboring gene tRNA methyltransferase O Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594 Neighboring gene acidic nuclear phosphoprotein 32 family member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
hemogen
Names
erythroid differentiation-associated gene protein
hemopoietic gene protein
negative differentiation regulator protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018437.5NP_060907.2  hemogen

    See identical proteins and their annotated locations for NP_060907.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF306682, AF322875, HY026328
    Consensus CDS
    CCDS6731.1
    UniProtKB/Swiss-Prot
    Q9BXL5
    UniProtKB/TrEMBL
    A0A024R162
    Related
    ENSP00000259456.2, ENST00000259456.7
  2. NM_197978.3NP_932095.1  hemogen

    See identical proteins and their annotated locations for NP_932095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF306682
    Consensus CDS
    CCDS6731.1
    UniProtKB/Swiss-Prot
    Q9BXL5
    UniProtKB/TrEMBL
    A0A024R162
    Related
    ENSP00000480020.1, ENST00000616898.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    97926791..97944852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252086.1XP_005252143.1  hemogen isoform X1

    See identical proteins and their annotated locations for XP_005252143.1

    UniProtKB/Swiss-Prot
    Q9BXL5
    UniProtKB/TrEMBL
    A0A024R162
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