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PPP5C protein phosphatase 5 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5536, updated on 6-Sep-2022

Summary

Official Symbol
PPP5Cprovided by HGNC
Official Full Name
protein phosphatase 5 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9322
See related
Ensembl:ENSG00000011485 MIM:600658; AllianceGenome:HGNC:9322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP5; PPT; PPP5
Summary
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See PPP5C in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46347087..46390975)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49174533..49218356)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46850344..46894232)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13463 Neighboring gene hypoxia inducible factor 3 subunit alpha Neighboring gene RNA, U6 small nuclear 924, pseudogene Neighboring gene uncharacterized LOC105372426 Neighboring gene coiled-coil domain containing 8 Neighboring gene PNMA family member 8C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36922, FLJ55954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 5
Names
PP-T
protein phosphatase T
NP_001191213.1
NP_006238.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028163.1 RefSeqGene

    Range
    5094..48982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204284.2NP_001191213.1  serine/threonine-protein phosphatase 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC007193, DA545760
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:212458
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd07417
    Location:176469
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam08321
    Location:138211
    PPP5; PPP5 TPR repeat region
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat
  2. NM_006247.4NP_006238.1  serine/threonine-protein phosphatase 5 isoform 1

    See identical proteins and their annotated locations for NP_006238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007193, BC001970
    Consensus CDS
    CCDS12684.1
    UniProtKB/Swiss-Prot
    P53041, Q53XV2
    UniProtKB/TrEMBL
    A0A024R0Q7
    Related
    ENSP00000012443.4, ENST00000012443.9
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:204480
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd15830
    Location:38153
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
    cd07417
    Location:176491
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46347087..46390975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49174533..49218356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)