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PPP5C protein phosphatase 5 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5536, updated on 17-Nov-2020

Summary

Official Symbol
PPP5Cprovided by HGNC
Official Full Name
protein phosphatase 5 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9322
See related
Ensembl:ENSG00000011485 MIM:600658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP5; PPT; PPP5
Summary
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues See more
Orthologs

Genomic context

See PPP5C in Genome Data Viewer
Location:
19q13.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46347069..46390975)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46850251..46896238)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 924, pseudogene Neighboring gene hypoxia inducible factor 3 subunit alpha Neighboring gene uncharacterized LOC105372426 Neighboring gene coiled-coil domain containing 8 Neighboring gene PNMA family member 8A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36922, FLJ55954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
histone dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
positive regulation of glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
response to arachidonic acid ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
proximal dendrite IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 5
Names
PP-T
protein phosphatase T
NP_001191213.1
NP_006238.1
XP_016882424.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028163.1 RefSeqGene

    Range
    5094..48982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204284.2NP_001191213.1  serine/threonine-protein phosphatase 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC007193, DA545760
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:212458
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd07417
    Location:176469
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam08321
    Location:138211
    PPP5; PPP5 TPR repeat region
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat
  2. NM_006247.4NP_006238.1  serine/threonine-protein phosphatase 5 isoform 1

    See identical proteins and their annotated locations for NP_006238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007193, BC001970
    Consensus CDS
    CCDS12684.1
    UniProtKB/Swiss-Prot
    P53041
    UniProtKB/TrEMBL
    A0A024R0Q7
    Related
    ENSP00000012443.4, ENST00000012443.9
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:204480
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd15830
    Location:38153
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
    cd07417
    Location:176491
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46347069..46390975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026935.2XP_016882424.1  serine/threonine-protein phosphatase 5 isoform X1

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