Ppp5c protein phosphatase 5, catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp5cprovided by MGI
Official Full Name: protein phosphatase 5, catalytic subunitprovided by MGI
Primary source: MGI:MGI:102666
See related: Ensembl:ENSMUSG00000003099 AllianceGenome:MGI:102666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP5
Summary: Enables RNA binding activity and phosphoprotein phosphatase activity. Acts upstream of or within response to morphine. Located in cytosol. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 54.8), cerebellum adult (RPKM 52.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 9.15 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (16738565..16761839, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (17004640..17027914, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation.
Title: PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation.
During inflammatory response to the bacterial LPS in the heart of transgenic mouse model with cardiac myocyte directed overexpression of protein phosphatase 5 (PP5) basal cardiac contractility was reduced, but LPS-induced cardiac dysfunction was less pronounced compared to wild type mice. PP5 increases stress tolerance of cardiac myocytes by downregulation of NF-kappaB signaling and upregulation of HSP25 expression.
Title: Overexpression of protein phosphatase 5 in the mouse heart: Reduced contractility but increased stress tolerance - Two sides of the same coin?
PP5 is a significant negative regulator on the regulation of bone and cartilage development.
Title: Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice.
PP5 directly interacts with and dephosphorylates p53 at multiple serine/threonine residues, resulting in inhibition of p53-mediated transcriptional activity.
Title: Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice.
PP5 binds and dephosphorylates the elastic N2B-unique sequence (N2Bus) of titin in cardiomyocytes. PP5 is pathologically elevated and likely contributes to hypo-phosphorylation of N2Bus in failing human hearts. Furthermore, Hsp90-activated PP5 interacts with components of a sarcomeric, N2Bus-associated, mechanosensor complex, and blocks mitogen-activated protein-kinase signaling in this complex.
Title: Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.
Mice with inactivated protein phosphatase 5 have decreased adipogenesis.
Title: Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5.
Ppp5c- knockout mice are resistant to weight gain induced by high fat diet.
Title: Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain.
Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
PP5 regulates the TGFbeta pathway in MEFs by regulating the expression of SMAD3 protein levels.
Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.
Data show that protein phosphatase 5 (PP5), a nuclear receptor co-chaperone, reciprocally modulates the lipometabolic activities of GRalpha and PPARgamma.
Title: Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ).

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126897 (e-PCR)
- UniSTS:208074

AW558946 (e-PCR)
- UniSTS:208075

Homology

Homologs of the Ppp5c gene: The Ppp5c gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 353 organisms have orthologs with human gene Ppp5c
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to arachidonic acid	ISO Inferred from Sequence Orthology more info
involved_in response to lead ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 5

Names: ANP receptor; protein phosphatase T

NP_035285.2

EC 3.1.3.16

XP_006539726.1

EC 3.1.3.16

XP_017177532.1

EC 3.1.3.16

XP_030098096.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417155.1 → NP_001404084.1 serine/threonine-protein phosphatase 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC148976
NM_011155.3 → NP_035285.2 serine/threonine-protein phosphatase 5 isoform 1

See identical proteins and their annotated locations for NP_035285.2

Status: VALIDATED

Source sequence(s)

AC148976

Consensus CDS

CCDS20859.1

UniProtKB/Swiss-Prot

O35299, Q60676

Related

ENSMUSP00000003183.6, ENSMUST00000003183.12

Conserved Domains (7) summary

smart00028
Location:28 → 61

TPR; Tetratricopeptide repeats

smart00156
Location:204 → 480

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

sd00006
Location:28 → 56

TPR; TPR repeat [structural motif]

cd07417
Location:176 → 491

MPP_PP5_C; PP5, C-terminal metallophosphatase domain

pfam00515
Location:96 → 129

TPR_1; Tetratricopeptide repeat

pfam13371
Location:71 → 134

TPR_9; Tetratricopeptide repeat

pfam13414
Location:27 → 93

TPR_11; TPR repeat

RNA

NR_184426.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC148976
NR_184427.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC148976

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

16738565..16761839 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322043.2 → XP_017177532.1 serine/threonine-protein phosphatase 5 isoform X1

Conserved Domains (1) summary

cd07417
Location:70 → 385

MPP_PP5_C; PP5, C-terminal metallophosphatase domain
XM_030242236.2 → XP_030098096.1 serine/threonine-protein phosphatase 5 isoform X1

Conserved Domains (1) summary

cd07417
Location:70 → 385

MPP_PP5_C; PP5, C-terminal metallophosphatase domain
XM_006539663.5 → XP_006539726.1 serine/threonine-protein phosphatase 5 isoform X1

Conserved Domains (1) summary

cd07417
Location:70 → 385

MPP_PP5_C; PP5, C-terminal metallophosphatase domain