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STRBP spermatid perinuclear RNA binding protein [ Homo sapiens (human) ]

Gene ID: 55342, updated on 6-Sep-2022

Summary

Official Symbol
STRBPprovided by HGNC
Official Full Name
spermatid perinuclear RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16462
See related
Ensembl:ENSG00000165209 MIM:611138; AllianceGenome:HGNC:16462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p74; SPNR; ILF3L; HEL162
Summary
Enables RNA binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within mechanosensory behavior and spermatid development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.5), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See STRBP in Genome Data Viewer
Location:
9q33.3
Exon count:
25
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123109494..123268586, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135318479..135465770, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125883548..126030865, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 8358 Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene uncharacterized LOC105376265 Neighboring gene uncharacterized LOC124902266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3405, FLJ11307, FLJ14223, FLJ14984, FLJ21960, MGC21529, DKFZp434N214

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mechanosensory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in manchette IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
spermatid perinuclear RNA-binding protein
Names
epididymis luminal protein 162
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171137.2NP_001164608.1  spermatid perinuclear RNA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001164608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR but has a downstream additional exon, which results in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the N-terminus.
    Source sequence(s)
    AL136866, AL365338, AL365504, BC002693
    Consensus CDS
    CCDS55337.1
    UniProtKB/Swiss-Prot
    Q96SI9
    Related
    ENSP00000354271.3, ENST00000360998.3
    Conserved Domains (4) summary
    smart00572
    Location:67320
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:594653
    SGP; Sulphur globule protein
    cd19909
    Location:370453
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:498561
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
  2. NM_001376106.1NP_001363035.1  spermatid perinuclear RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    UniProtKB/Swiss-Prot
    Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Conserved Domains (4) summary
    smart00572
    Location:81334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608667
    SGP; Sulphur globule protein
    cd19909
    Location:384467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
  3. NM_001376107.1NP_001363036.1  spermatid perinuclear RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    UniProtKB/Swiss-Prot
    Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Conserved Domains (4) summary
    smart00572
    Location:81334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608667
    SGP; Sulphur globule protein
    cd19909
    Location:384467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
  4. NM_001376109.1NP_001363038.1  spermatid perinuclear RNA-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    Conserved Domains (3) summary
    smart00572
    Location:81334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19909
    Location:384467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
  5. NM_018387.5NP_060857.2  spermatid perinuclear RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_060857.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL365338, AL365504, BC002693, BC017732
    Consensus CDS
    CCDS6851.1
    UniProtKB/Swiss-Prot
    Q96SI9, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Related
    ENSP00000321347.7, ENST00000348403.10
    Conserved Domains (4) summary
    smart00572
    Location:81334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608667
    SGP; Sulphur globule protein
    cd19909
    Location:384467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

RNA

  1. NR_033234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has several alternate splice sites, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate.
    Source sequence(s)
    AL365338, AL365504, AL834150, BC108731

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    123109494..123268586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423563.1XP_047279519.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5K8
  2. XM_047423562.1XP_047279518.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Related
    ENSP00000415968.2, ENST00000447404.6

RNA

  1. XR_007061327.1 RNA Sequence

  2. XR_007061326.1 RNA Sequence

  3. XR_001746347.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    135318479..135465770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)