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SHFL shiftless antiviral inhibitor of ribosomal frameshifting [ Homo sapiens (human) ]

Gene ID: 55337, updated on 5-Jan-2022

Summary

Official Symbol
SHFLprovided by HGNC
Official Full Name
shiftless antiviral inhibitor of ribosomal frameshiftingprovided by HGNC
Primary source
HGNC:HGNC:25649
See related
Ensembl:ENSG00000130813 MIM:616808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFL; IRAV; RyDEN; C19orf66
Summary
This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues See more
Orthologs
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Genomic context

See SHFL in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10086119..10093249)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10196993..10203919)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5589 Neighboring gene complement component 3 precursor pseudogene Neighboring gene angiopoietin like 6 Neighboring gene PPAN-P2RY11 readthrough Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11286, FLJ40743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
shiftless antiviral inhibitor of ribosomal frameshifting protein
Names
Repressor of yield of Dengue virus
UPF0515 protein C19orf66
interferon-regulated antiviral protein
repressor of yield of DENV protein
shiftless

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308277.2NP_001295206.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 2

    See identical proteins and their annotated locations for NP_001295206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    BC026180, BC035817, DB481173
    Consensus CDS
    CCDS77231.1
    UniProtKB/Swiss-Prot
    Q9NUL5
    Related
    ENSP00000467182.1, ENST00000591813.5
    Conserved Domains (1) summary
    pfam15135
    Location:16232
    UPF0515; Uncharacterized protein UPF0515
  2. NM_018381.4NP_060851.2  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 1

    See identical proteins and their annotated locations for NP_060851.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK002148, BC010847, DB481173
    Consensus CDS
    CCDS45957.1
    UniProtKB/Swiss-Prot
    Q9NUL5
    Related
    ENSP00000253110.10, ENST00000253110.16
    Conserved Domains (1) summary
    pfam15135
    Location:16268
    UPF0515; Uncharacterized protein UPF0515

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10086119..10093249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528121.1XP_011526423.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X1

    Related
    ENSP00000380978.3, ENST00000397881.7
    Conserved Domains (1) summary
    pfam15135
    Location:25229
    UPF0515; Uncharacterized protein UPF0515
  2. XM_011528122.1XP_011526424.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X2

    Conserved Domains (1) summary
    pfam15135
    Location:1678
    UPF0515; Uncharacterized protein UPF0515
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