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DRAM1 DNA damage regulated autophagy modulator 1 [ Homo sapiens (human) ]

Gene ID: 55332, updated on 22-Sep-2022

Summary

Official Symbol
DRAM1provided by HGNC
Official Full Name
DNA damage regulated autophagy modulator 1provided by HGNC
Primary source
HGNC:HGNC:25645
See related
Ensembl:ENSG00000136048 MIM:610776; AllianceGenome:HGNC:25645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAM
Summary
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 41.9), urinary bladder (RPKM 12.1) and 20 other tissues See more
Orthologs
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Genomic context

See DRAM1 in Genome Data Viewer
Location:
12q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (101877580..101923612)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (101838785..101884733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102271358..102317390)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1183, pseudogene Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 5561 Neighboring gene ribosomal protein L9 pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA damage-regulated autophagy modulator protein 1
Names
damage-regulated autophagy modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018370.3NP_060840.2  DNA damage-regulated autophagy modulator protein 1

    See identical proteins and their annotated locations for NP_060840.2

    Status: REVIEWED

    Source sequence(s)
    AC084398, AI079438, BC018435
    Consensus CDS
    CCDS41823.1
    UniProtKB/Swiss-Prot
    Q8N682, Q9NUN1
    UniProtKB/TrEMBL
    A0A024RBF9
    Related
    ENSP00000258534.8, ENST00000258534.13
    Conserved Domains (1) summary
    pfam10277
    Location:7224
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    101877580..101923612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269004.3XP_005269061.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:7188
    Frag1; Frag1/DRAM/Sfk1 family
  2. XM_005269005.3XP_005269062.1  DNA damage-regulated autophagy modulator protein 1 isoform X3

    Related
    ENSP00000445827.1, ENST00000544152.5
    Conserved Domains (1) summary
    pfam10277
    Location:7146
    Frag1; Frag1/DRAM/Sfk1 family
  3. XM_047429098.1XP_047285054.1  DNA damage-regulated autophagy modulator protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    101838785..101884733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)