U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dram1 DNA-damage regulated autophagy modulator 1 [ Mus musculus (house mouse) ]

Gene ID: 71712, updated on 2-May-2024

Summary

Official Symbol
Dram1provided by MGI
Official Full Name
DNA-damage regulated autophagy modulator 1provided by MGI
Primary source
MGI:MGI:1918962
See related
Ensembl:ENSMUSG00000020057 AllianceGenome:MGI:1918962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dram; 1200002N14Rik
Summary
Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within apoptotic process and autophagy. Predicted to be located in cytoplasm. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; genitourinary system; gut; integumental system; and respiratory system. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 132.8), subcutaneous fat pad adult (RPKM 43.3) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dram1 in Genome Data Viewer
Location:
10 C1; 10 43.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88158663..88200218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88322801..88364359, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene predicted gene 8415 Neighboring gene WD repeat domain 75 pseudogene Neighboring gene predicted gene, 51779 Neighboring gene STARR-positive B cell enhancer ABC_E2332 Neighboring gene STARR-positive B cell enhancer ABC_E11453 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene STARR-positive B cell enhancer ABC_E5162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:87872706-87873007 Neighboring gene STARR-positive B cell enhancer ABC_E2333 Neighboring gene STARR-positive B cell enhancer ABC_E3906

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA damage-regulated autophagy modulator protein 1
Names
damage-regulated autophagy modulator

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417838.1NP_001404767.1  DNA damage-regulated autophagy modulator protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125486
  2. NM_027878.3NP_082154.2  DNA damage-regulated autophagy modulator protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082154.2

    Status: VALIDATED

    Source sequence(s)
    AC125486
    Consensus CDS
    CCDS24109.1
    UniProtKB/Swiss-Prot
    Q78J26, Q9DC58
    Related
    ENSMUSP00000020249.2, ENSMUST00000020249.2
    Conserved Domains (1) summary
    pfam10277
    Location:7224
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_184639.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125486

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88158663..88200218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243576.3XP_011241878.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011241878.1

    Conserved Domains (1) summary
    pfam10277
    Location:1166
    Frag1; Frag1/DRAM/Sfk1 family
  2. XM_017314100.2XP_017169589.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:1166
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. XR_004936281.1 RNA Sequence