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Dram1 DNA-damage regulated autophagy modulator 1 [ Mus musculus (house mouse) ]

Gene ID: 71712, updated on 12-Mar-2023

Summary

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Official Symbol
Dram1provided by MGI
Official Full Name
DNA-damage regulated autophagy modulator 1provided by MGI
Primary source
MGI:MGI:1918962
See related
Ensembl:ENSMUSG00000020057 AllianceGenome:MGI:1918962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dram; 1200002N14Rik
Summary
Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within apoptotic process and autophagy. Predicted to be located in cytoplasm. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; genitourinary system; gut; integumental system; and respiratory system. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 132.8), subcutaneous fat pad adult (RPKM 43.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Dram1 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88158663..88200218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88322801..88364359, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene predicted gene 8415 Neighboring gene WD repeat domain 75 pseudogene Neighboring gene predicted gene, 51779 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice. Chen G, et al. Mol Med Rep, 2020 Sep. PMID 32582984, Free PMC Article
  2. DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. Yu M, et al. Int J Mol Sci, 2014 Oct 23. PMID 25342320, Free PMC Article
  3. DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease. Zhang Y, et al. Dig Dis Sci, 2021 Oct. PMID 33184797
  4. mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, et al. Mol Cell, 2019 Oct 3. PMID 31492633, Free PMC Article
  5. DRAM-1 encodes multiple isoforms that regulate autophagy. Mah LY, et al. Autophagy, 2012 Jan. PMID 22082963, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
    Title: DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
  2. DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
    Title: DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
  3. Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.
    Title: Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.
  4. DRAM-1 binds the membrane carrier protein SCAMP3 and the amino acid transporters SLC1A5 and LAT1, directing them to lysosomes and permitting efficient mTORC1 activation.
    Title: mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.
  5. DRAM1 knockdown aggravates OGD/R-induced cell injury.
    Title: DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
  6. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
    Title: DRAM-1 encodes multiple isoforms that regulate autophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA damage-regulated autophagy modulator protein 1
Names
damage-regulated autophagy modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417838.1 → NP_001404767.1  DNA damage-regulated autophagy modulator protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125486

  2. NM_027878.3 → NP_082154.2  DNA damage-regulated autophagy modulator protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082154.2

    Status: VALIDATED

    Source sequence(s)
    AC125486
    Consensus CDS
    CCDS24109.1
    UniProtKB/Swiss-Prot
    Q78J26, Q9DC58
    UniProtKB/TrEMBL
    A0A8C6IJR3
    Related
    ENSMUSP00000020249.2, ENSMUST00000020249.2
    Conserved Domains (1) summary
    pfam10277
    Location:7 → 224
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_184639.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125486

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88158663..88200218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243576.3 → XP_011241878.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011241878.1

    Conserved Domains (1) summary
    pfam10277
    Location:1 → 166
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_017314100.2 → XP_017169589.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:1 → 166
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. XR_004936281.1 RNA Sequence

  2. XR_380446.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC58.2 GenPept UniProtKB/Swiss-Prot:Q9DC58

Gene LinkOut

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